protein 1,300 words KG: ARG1PROTEIN
Contents

ARG1 Protein

🔬 Protein Info
Gene SymbolARG1
Full NameArginase 1
AliasesArginase-1, Liver arginase
Chromosome6q23.2
FunctionUrea cycle enzyme, hydrolyzes arginine to ornithine
Primary Expressionthe brain, where it plays important roles in modulating nitric oxide (NO) production, polyamine synthesis, and immune cell function[^2]
Molecular Weight34.7 kDa
Amino Acids330
PathwaysUrea cycle, Arginine metabolism
UniProt IDP05089
NCBI Gene ID383
Ensembl IDENSG00000118520
OMIM608313
GeneCardsARG1
Human Protein AtlasARG1
Associated DiseasesAging, Alzheimer, Cancer, Dementia, Ms, Tumor
InteractionsABCA1, ABCG1, AHR, AKT, AMPK, AND
KG Connections223 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Related Hypotheses (17)

Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.43
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Orexin-Microglia Modulation Therapy
Score: 0.71
Complement C1q Mimetic Decoy Therapy
Score: 0.69
Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68
Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution
Score: 0.68
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56

Related Analyses (13)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

Related Experiments (1)

QTJD effects on macrophage polarization and inflammatory res
exploratory · proposed · Score: 0.95

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Exosomal miR-155 in Neurodegeneration
biomarker · Pages share 3 hypotheses
Synaptic Biomarkers in Neurodegeneration
biomarker · Pages share 3 hypotheses
Liquid Biopsy in Neurodegeneration
biomarker · Pages share 3 hypotheses
Metabolomic Biomarkers in Neurodegeneration
biomarker · Pages share 3 hypotheses

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