concept

PERICYTES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PERICYTES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

387Connections

2Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

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💡 Concept Info

Name	PERICYTES
Key Genes/Proteins	AD, AKT, ALS, AMPK, AMYLOID, APOE
Related Diseases	ALZHEIMER, ALZHEIMER'S, Alzheimer'S Disease, ALZHEIMER'S DISEASE
Related Pathways	APOPTOSIS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Pericytes

cell · 2272 words

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Pathway Diagram

graph TD
    PERICYTES["PERICYTES"]
    style PERICYTES fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    PERICYTES -->|"component_of"| Neurovascular_Unit["Neurovascular Unit"]
    PERICYTES -->|"involved_in"| Blood_Brain_Barrier["Blood-Brain Barrier"]
    PERICYTES -->|"regulates"| SENESCENCE["SENESCENCE"]
    PERICYTES -->|"activates"| VEGF([VEGF])
    SMAD3([SMAD3]) -->|"expressed in"| PERICYTES
    KATP([KATP]) -->|"expressed in"| PERICYTES
    PERICYTE["/PERICYTE/"] -->|"causes"| PERICYTES
    AUTOPHAGY["AUTOPHAGY"] -->|"regulates"| PERICYTES
    ASTROCYTE["/ASTROCYTE/"] -->|"activates"| PERICYTES
    ASTROCYTES["/ASTROCYTES/"] -->|"activates"| PERICYTES
    ENDOTHELIAL["/ENDOTHELIAL/"] -->|"contributes to"| PERICYTES

Outgoing (54)

Target	Relation	Type	Str
Neurovascular Unit	component_of	process	0.95
Blood-Brain Barrier	involved_in	process	0.95
vascular barrier function	promotes	process	0.90
blood-brain barrier integrity	associated_with	phenotype	0.85
Neurovascular Unit	involved_in	process	0.82
RAGE	markers	gene	0.70
VEGF	activates	gene	0.65
STING	interacts_with	gene	0.60
SMPD1	expresses	gene	0.60
STING	targets	gene	0.60
Alzheimer's disease	associated_with	disease	0.60
Alzheimer's disease	activates	disease	0.60
VEGF	inhibits	gene	0.60
ENDOTHELIAL CELLS	associated_with	cell_type	0.60
STING	stabilizes	gene	0.60
apoptosis pathway	active_in	pathway	0.55
oxidative stress response	active_in	pathway	0.55
calcium signaling	active_in	pathway	0.55
blood-brain barrier	active_in	pathway	0.55
TNF	co_discussed	entity	0.50
SLEEP	co_discussed	entity	0.50
TAU	co_discussed	entity	0.50
SMPD1	co_discussed	entity	0.50
PERICYTE	causes	entity	0.50
SPINAL CORD	co_discussed	entity	0.50
T CELLS	co_discussed	entity	0.50
STING	co_discussed	entity	0.50
PRION-LIKE	co_discussed	entity	0.50
EXTRACELLULAR VESICLES	associated_with	concept	0.50
FIBROBLASTS	associated_with	concept	0.50
B CELLS	associated_with	concept	0.50
EXTRACELLULAR MATRIX	associated_with	concept	0.50
ENDOTHELIAL CELLS	activates	concept	0.50
IPSC	activates	concept	0.50
CENTRAL NERVOUS SYSTEM	activates	concept	0.50
ENDOTHELIAL CELLS	inhibits	concept	0.50
CENTRAL NERVOUS SYSTEM	regulates	concept	0.50
FIBROBLASTS	activates	concept	0.50
ENDOTHELIAL CELLS	interacts_with	concept	0.50
T CELL	co_discussed	entity	0.50
STROKE	co_discussed	entity	0.50
SENESCENCE	co_discussed	entity	0.50
SYNAPSE	co_discussed	entity	0.50
WHITE MATTER	co_discussed	entity	0.50
VEGF	co_discussed	gene	0.40
RAPAMYCIN	activates	drug	0.35
SEPSIS	regulates	disease	0.35
SENESCENCE	activates	process	0.35
SENESCENCE	associated_with	process	0.35
SENESCENCE	therapeutic_target	process	0.35

Incoming (333)

Source	Relation	Type	Str
S100B	causes_contraction	protein	0.00
ENDOTHELIAL CELLS	interacts_with	cell_type	0.95
SMAD3	expressed_in	gene	0.95
35165441	have two subtypes marked by	paper	0.90
25757756	maintain	paper	0.90
Ion Channels	expressed_in	protein	0.90
TMEM16A	expressed_in	gene	0.85
KATP	expressed_in	protein	0.85
Alzheimer's disease	affects	disease	0.80
MICROGLIA	causes	cell_type	0.70
PERICYTE	degrades	cell_type	0.70
NEURONS	mediates	cell_type	0.70
LRRK2	associated_with	gene	0.70
ASTROCYTE	targets	cell_type	0.70
PERICYTE	expressed_in	cell_type	0.70
MICROGLIA	interacts_with	cell_type	0.70
ENDOTHELIAL	targets	cell_type	0.70
PDGF	associated_with	gene	0.70
ENDOTHELIAL	expresses	cell_type	0.70
ASTROCYTE	mediates	cell_type	0.70
OLIGODENDROCYTE	inhibits	cell_type	0.70
ASTROCYTE	causes	cell_type	0.70
HUNTINGTON'S DISEASE	interacts_with	disease	0.70
PERICYTE	enhances	cell_type	0.70
AMPK	activates	gene	0.70
CREB	activates	gene	0.70
MICROGLIA	expresses	cell_type	0.70
NEURONS	expresses	cell_type	0.70
NEURONS	enhances	cell_type	0.70
NEURONS	disrupts	cell_type	0.70
MICROGLIA	disrupts	cell_type	0.70
ENDOTHELIAL	disrupts	cell_type	0.70
ASTROCYTE	disrupts	cell_type	0.70
NEURONS	targets	cell_type	0.70
OLIGODENDROCYTE	disrupts	cell_type	0.70
MACROPHAGE	activates	cell_type	0.70
APOE	regulates	gene	0.70
PERICYTE	targets	cell_type	0.70
APOE	stabilizes	gene	0.70
OLIGODENDROCYTES	disrupts	cell_type	0.70
ROS	expressed_in	gene	0.70
VEGFA	expressed_in	gene	0.70
SARS	expressed_in	gene	0.70
unfolded protein response	active_in	pathway	0.70
PERICYTE	regulates	cell_type	0.65
PERICYTE	activates	cell_type	0.65
ASTROCYTES	activates	cell_type	0.65
APP	expressed_in	gene	0.65
ASTROCYTE	activates	cell_type	0.65
PERICYTE	causes	cell_type	0.65

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Pericyte-targeted senolysis or senomorphic therapy will bene	0.700	neurodegeneration	Does pericyte senescence drive BBB break
Chronic mTORC1-ULK1 signaling blocks autophagy initiation in	0.578	neurodegeneration	What specific autophagy pathways are def

Mentioning Analyses (1)

Scientific analyses that reference this entity

What blood-brain barrier permeability changes serve as early biomarkers for neur

neurodegeneration | 2026-04-26 | 8 hypotheses Top: 0.710

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What blood-brain barrier permeability changes serve as early biomarkers for neur

active · Rounds: 4 · Score: 1.00 · 2026-04-26

Related Research

Hypotheses and analyses mentioning PERICYTES in their description or question text

No additional research found