concept

GLP1R

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GLP1R: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

345Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

GLP1R is a concept in neurodegeneration research. Key relationships include: interacts with, inhibits, expressed in. Associated with ALS, Als, Hepatitis. Connected to 93 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	GLP1R
Key Genes/Proteins	AADC, ACOX1, Adiponectin, ADIPOQ, AHR, AHR, IL10, TGFB1
Related Diseases	Als, ALS, Alzheimer, ALZHEIMER, Alzheimer's disease
Related Pathways	Amyloid

🧬 3D Structure Comparison — GLP1R Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

6X18 — X-ray / Cryo-EM

🔮 AI Predicted Structure

P43220 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Pathway Diagram

graph TD
    GLP1R["GLP1R"]
    GLP1R -->|"inhibits"| Als["Als"]
    GLP1R -->|"interacts"| Tumor["Tumor"]
    GLP1R -->|"interacts"| Hepatitis["Hepatitis"]
    GLP1R -->|"inhibits"| ALS["ALS"]
    GLP1R -->|"interacts"| BDNF["BDNF"]
    GLP1R -->|"inhibits"| GFRAL["GFRAL"]
    GLP1R -->|"inhibits"| GDNF["GDNF"]
    GLP1R -->|"interacts"| SREBF1["SREBF1"]
    GLP1R -->|"interacts"| SIRT1["SIRT1"]
    h_ee1df336["h-ee1df336"] -->|"targets"| GLP1R
    BDNF -->|"interacts"| GLP1R
    PPARA["PPARA"] -->|"interacts"| GLP1R
    ULK1["ULK1"] -->|"interacts"| GLP1R
    STX17["STX17"] -->|"interacts"| GLP1R
    SQSTM1["SQSTM1"] -->|"interacts"| GLP1R
    NOS3["NOS3"] -->|"interacts"| GLP1R
    STING1["STING1"] -->|"interacts"| GLP1R
    GDNF -->|"inhibits"| GLP1R

Outgoing (208)

Target	Relation	Type	Str
BDNF neurons	regulates	cell_type	0.80
NLY01	activates	drug	0.80
astrocyte_reactivity	modulates	phenotype	0.70
ARAP3	activates	gene	0.70
ARAP3	regulates	gene	0.70
ALS	inhibits	disease	0.65
Als	activates	disease	0.65
Tumor	interacts_with	disease	0.65
Hepatitis	interacts_with	disease	0.65
Alzheimer	expressed_in	disease	0.65
Als	inhibits	disease	0.65
neurodegeneration	associated_with	disease	0.62
BDNF	interacts_with	gene	0.62
KDM6B	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
PRKAA2	interacts_with	gene	0.60
LAMP2	interacts_with	gene	0.60
PLIN3	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
GRK2	interacts_with	gene	0.60
FOXO1	interacts_with	gene	0.60
NR1H3	interacts_with	gene	0.60
MAP3K5	interacts_with	gene	0.60
SREBF2	interacts_with	gene	0.60
NFE2L2	interacts_with	gene	0.60
C1Q	interacts_with	gene	0.60
HTRA2	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
SIRT3	interacts_with	gene	0.60
PLIN2	interacts_with	gene	0.60
TP53	interacts_with	gene	0.60
GRK2	activates	entity	0.60
HTRA2	activates	entity	0.60
KDM6B	activates	entity	0.60
LAMP2	activates	entity	0.60
LC3	activates	entity	0.60
MAP3K5	activates	entity	0.60
MTOR	activates	entity	0.60
NFE2L2	activates	entity	0.60
NOS3	activates	entity	0.60
NR1H3	activates	entity	0.60
P62	activates	entity	0.60
PLIN2	activates	entity	0.60
PLIN3	activates	entity	0.60
PPARA	activates	entity	0.60
PRKAA2	activates	entity	0.60
RPTOR	activates	entity	0.60
SIRT1	activates	entity	0.60
SIRT3	activates	entity	0.60

Incoming (137)

Source	Relation	Type	Str
h-ee1df336	targets	hypothesis	0.90
BDNF	interacts_with	gene	0.62
TFEB	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
NR1H3	interacts_with	gene	0.60
MAP3K5	interacts_with	gene	0.60
LAMP2	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
HTRA2	interacts_with	gene	0.60
PRKAA2	interacts_with	gene	0.60
GRK2	interacts_with	gene	0.60
FOXO1	interacts_with	gene	0.60
SIRT1	interacts_with	gene	0.60
NFE2L2	interacts_with	gene	0.60
TP53	interacts_with	gene	0.60
AMPK	activates	entity	0.60
SREBF2	interacts_with	gene	0.60
PLIN2	interacts_with	gene	0.60
PLIN3	interacts_with	gene	0.60
GDNF	expressed_in	entity	0.60
GFRAL	expressed_in	entity	0.60
DYRK1A	activates	gene	0.60
DYRK1A	inhibits	gene	0.60
KDM6B	interacts_with	gene	0.60
EGFR	activates	gene	0.60
BDNF	expressed_in	gene	0.60
EGFR	expressed_in	gene	0.60
MTORC1	interacts_with	gene	0.60
EGFR	inhibits	gene	0.60
EGFR	promotes	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
FOXO1	activates	entity	0.60
ADIPOQ	activates	gene	0.60
RAS	interacts_with	gene	0.60
ATG	activates	gene	0.60
AMPK	regulates	gene	0.60
ATG	regulates	gene	0.60
CREB	regulates	gene	0.60
ACOX1	activates	gene	0.60
rapamycin	targets	drug	0.60
GFRAL	associated_with	gene	0.60
PPARA	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
STX17	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
NOS3	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Astrocyte Reactivity Subtypes in Neurodegeneration

neurodegeneration | 2026-04-01 | 0 hypotheses

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.924

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Astrocyte Reactivity Subtypes in Neurodegeneration

closed · Rounds: 4 · Score: 0.95 · 2026-04-09

What are the mechanisms underlying what are the mechanisms by which gut microbio

closed · Rounds: 4 · Score: 0.95 · 2026-04-01

Related Research

Hypotheses and analyses mentioning GLP1R in their description or question text

No additional research found