Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about AHR, IL10, TGFB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | AHR, IL10, TGFB1 |
| Key Genes/Proteins | CLDN1, OCLN, ZO1, MLCK, GLP1R, GLP1R, BDNF, NLRP3, CASP1, IL1B, PYCARD, SNCA, HSPA1A, DNMT1, TH, AADC |
| Related Diseases | neurodegeneration |
graph TD
AHR__IL10__TGFB1[AHR, IL10, TGFB1]
AHR__IL10__TGFB1 -->|debate_co_mention| CLDN1__OCLN__ZO1__MLCK[CLDN1, OCLN, ZO1, MLCK]
AHR__IL10__TGFB1 -->|debate_co_mention| GLP1R[GLP1R]
AHR__IL10__TGFB1 -->|debate_co_mention| GLP1R__BDNF[GLP1R, BDNF]
AHR__IL10__TGFB1 -->|debate_co_mention| neuroinflammation[neuroinflammation]
AHR__IL10__TGFB1 -->|implicated in| neurodegeneration[neurodegeneration]
AHR__IL10__TGFB1 -->|co_associated_with| NLRP3__CASP1__IL1B__PYCARD[NLRP3, CASP1, IL1B, PYCARD]
AHR__IL10__TGFB1 -->|co_associated_with| SNCA__HSPA1A__DNMT1[SNCA, HSPA1A, DNMT1]
AHR__IL10__TGFB1 -->|co_associated_with| TH__AADC[TH, AADC]
h_f9c6fa3f[h-f9c6fa3f] -->|targets| AHR__IL10__TGFB1
benchmark_ot_ad_answer_key_AHR[benchmark_ot_ad_answer_key:AHR, IL10, TGFB1] -->|data_in| AHR__IL10__TGFB1| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:AHR, IL10, TGFB1 | data_in | dataset_row | 0.00 |
| CLDN1, OCLN, ZO1, MLCK | debate_co_mention | gene | 0.45 |
| GLP1R | debate_co_mention | gene | 0.45 |
| GLP1R, BDNF | debate_co_mention | gene | 0.45 |
| neuroinflammation | debate_co_mention | process | 0.45 |
| neurodegeneration | associated_with | disease | 0.40 |
| CLDN1, OCLN, ZO1, MLCK | co_associated_with | gene | 0.40 |
| GLP1R, BDNF | co_associated_with | gene | 0.40 |
| NLRP3, CASP1, IL1B, PYCARD | co_associated_with | gene | 0.40 |
| SNCA, HSPA1A, DNMT1 | co_associated_with | gene | 0.40 |
| TH, AADC | co_associated_with | gene | 0.40 |
| TLR4, SNCA | co_associated_with | gene | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:AHR, IL10, TGFB1 | data_in | dataset_row | 0.00 |
| h-f9c6fa3f | targets | hypothesis | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Microbiome-Derived Tryptophan Metabolite Neuroprotection | 0.427 | neurodegeneration | What are the mechanisms by which gut mic |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.907
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| IL-10 deficiency and VLC ceramide accumulation in inflammatory bowel d | validation | inflammatory bowel disease | 0.900 | 0.00 | IL-10 knockout mice | proposed | N/A |
| Gut-Brain Axis Pathogenesis in Parkinson's Disease — Mechanism and Int | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propagation | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Microbiome-Gut Barrier Signatures in ALS — Experiment Design | clinical | ALS | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Microbiome-Gut-Brain Axis in Alzheimer's Disease — mechanism and inter | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
| SCFA-Mediated Neuroinflammation in Alzheimer's Disease | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Gut microbiota-derived indoleacetic acid attenuates neuroinflammation and neurod [PMID:40640940] | Wang N, Sun C, Yang Y | J Neuroinflammation | 2025 | 0 |
| A review on immunomodulatory effects of BPA analogues. [PMID:37204436] | ["Kodila A", "Franko N", "Sollner Dolenc | Archives of toxicology | 2023 | 0 |
| Current Therapeutic Landscape and Safety Roadmap for Targeting the Aryl Hydrocar [PMID:35626744] | ["Faber S", "Lahoti T", "Taylor E", "Lew | Cells | 2022 | 0 |
| Gene editing. [PMID:32641840] | Unknown | Nature biotechnology | 2020 | 0 |
| Targeting Aryl hydrocarbon receptor for next-generation immunotherapies: Selecti [PMID:31727470] | ["Dolciami D", "Ballarotto M", "Gargaro | European journal of medicinal | 2020 | 0 |
| Single-cell reconstruction of the adult human heart during heart failure and rec [PMID:31915373] | ["Wang L", "Yu P", "Zhou B", "Song J", " | Nature cell biology | 2020 | 0 |
| The Aryl Hydrocarbon Receptor: A Mediator and Potential Therapeutic Target for O [PMID:32947781] | ["Choudhary M", "Malek G"] | International journal of molec | 2020 | 0 |
| Physiologic maturation is both extrinsically and intrinsically regulated in prog [PMID:32047174] | ["Venugopalan P", "Cameron E", "Zhang X" | Scientific reports | 2020 | 0 |
| ilastik: interactive machine learning for (bio)image analysis. [PMID:31570887] | ["Berg S", "Kutra D", "Kroeger T", "Stra | Nature methods | 2019 | 0 |
| Incorporation of oxygen atoms as a mechanism for photoluminescence enhancement o [PMID:29904778] | ["Schwermann C", "Stiehm T", "Tonndorf P | Physical chemistry chemical ph | 2018 | 0 |
| [Effect of alexithymia on health anxiety: Mediating role of cognition and meta-c [PMID:30333296] | ["Dai L", "Zhou Y", "Hu J", "Deng Y"] | Zhong nan da xue xue bao. Yi x | 2018 | 0 |
| Nicotinamide mononucleotide attenuates brain injury after intracerebral hemorrha [PMID:28386082] | ["Wei C", "Kong Y", "Li G", "Guan Y", "W | Scientific reports | 2017 | 0 |
| The Genetic Landscape of β-Cell Proliferation: Toward a Road Map. [PMID:27329954] | Bridget K Wagner | Diabetes | 2016 | 0 |
| Guidelines for the use and interpretation of assays for monitoring autophagy (3r [PMID:26799652] | Klionsky DJ, Abdelmohsen K, Abe A | Autophagy | 2016 | 0 |
| Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic ste [PMID:23934149] | ["Yan L", "Yang M", "Guo H", "Yang L", " | Nature structural & molecular | 2013 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning AHR, IL10, TGFB1 in their description or question text
No additional research found