gene

GFRAL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GFRAL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

79Connections

1Hypotheses

0Analyses

50Outgoing

20Incoming

0Experiments

0Debates

Summary

GFRAL is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, activates, inhibits. Associated with ALS, Als, Autoimmune. Connected to 43 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	GFRAL
Full Name	GDNF Receptor Alpha Like
Aliases	Page for GFRAL Gene, Page for GFRAL Protein
Chromosome	6p12.1
Protein Type	Receptor
Function	is a cell surface receptor that belongs to the GDNF receptor family (GFRα).
Primary Expression	specific neuronal populations: - Substantia nigra pars compacta: Dopaminergic neurons - Ventral tegmental area: Mesolimbic dopamine neurons -
Molecular Weight	50 kDa
Pathways	PI3K
UniProt ID	Q6UXB5
NCBI Gene ID	390538
Ensembl ID	ENSG00000173137
OMIM	615866
GeneCards	GFRAL
Human Protein Atlas	GFRAL
Associated Diseases	ALS
Interactions	ADCY3, AND, CANCER, CYTOKINES, GDF15, Gdnf
KG Connections	79 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GFRAL — AlphaFold Q6UXB5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

GFRAL Gene - GDNF Receptor Alpha Like

gene · 871 words

→

GFRAL Protein - GDNF Receptor Alpha Like

protein · 856 words

→

Pathway Diagram

graph TD
    GFRAL["GFRAL"]
    BDNF_mNTS_Neurons["BDNF mNTS Neurons"]
    GFRAL -->|"activates"| BDNF_mNTS_Neurons
    GLP1R["GLP1R"]
    GFRAL -->|"co expressed with"| GLP1R
    Als{"Als"}
    GFRAL -->|"inhibits"| Als
    GFRAL -->|"activates"| Als
    Cancer{"Cancer"}
    GFRAL -->|"inhibits"| Cancer
    Tumor{"Tumor"}
    GFRAL -->|"inhibits"| Tumor
    Ms{"Ms"}
    GFRAL -->|"activates"| Ms
    ALS{"ALS"}
    GFRAL -->|"inhibits"| ALS
    Obesity{"Obesity"}
    GFRAL -->|"therapeutic target"| Obesity
    Inflammation{"Inflammation"}
    GFRAL -->|"activates"| Inflammation
    GDNF["GDNF"]
    GFRAL -->|"inhibits"| GDNF
    BDNF["BDNF"]
    GFRAL -->|"contributes to"| BDNF
    GDF15["GDF15"]
    GDF15 -->|"binds"| GFRAL
    BDNF -->|"contributes to"| GFRAL
    GLP1R -->|"inhibits"| GFRAL
    GDNF -->|"inhibits"| GFRAL
    IL_6["IL-6"]
    IL_6 -->|"inhibits"| GFRAL
    CANCER["CANCER"]
    CANCER -->|"inhibits"| GFRAL
    HDAC6["HDAC6"]
    HDAC6 -->|"activates"| GFRAL
    GDNF -->|"regulates"| GFRAL
    SHH["SHH"]
    SHH -->|"activates"| GFRAL
    AND["AND"]
    AND -->|"therapeutic target"| GFRAL
    CYTOKINES["CYTOKINES"]
    CYTOKINES -->|"activates"| GFRAL
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"activates"| GFRAL
    style GFRAL fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (59)

Target	Relation	Type	Str
BDNF neurons	regulates	cell_type	0.80
Obesity	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Als	regulates	disease	0.65
Atherosclerosis	regulates	disease	0.65
Cancer	regulates	disease	0.65
Myocardial Infarction	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Autoimmune	therapeutic_target	disease	0.65
ALS	inhibits	disease	0.65
Als	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Ischemia	therapeutic_target	disease	0.65
ALS	regulates	disease	0.65
Heart Failure	regulates	disease	0.65
Tumor	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Obesity	therapeutic_target	disease	0.65
Inflammation	activates	disease	0.65
Ms	activates	disease	0.65
Als	inhibits	disease	0.65
T cells	expressed_in	cell_type	0.60
oxidative stress response	participates_in	pathway	0.60
blood-brain barrier	participates_in	pathway	0.60
Bdnf	contributes_to	protein	0.60
GLP1R	associated_with	gene	0.60
GDNF	inhibits	gene	0.60
GDNF	activates	gene	0.60
neuroinflammation	activates	disease	0.60
GLP1R	expressed_in	entity	0.60
Hedgehog	activates	pathway	0.60
Immune Response	therapeutic_target	pathway	0.60
HEDGEHOG	activates	gene	0.60
ALS	associated_with	disease	0.60
GDNF	regulates	gene	0.60
Gdnf	associated_with	protein	0.60
neurons	expressed_in	cell_type	0.60
GLP1R	inhibits	gene	0.60
ADCY3	activates	gene	0.60
GDNF	associated_with	gene	0.60
CANCER	regulates	gene	0.60
Tgf-Β	regulates	pathway	0.60
BDNF	contributes_to	gene	0.60
Er Stress	therapeutic_target	pathway	0.60
INFLAMMATION	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
Differentiation	therapeutic_target	pathway	0.60
Immunotherapy	therapeutic_target	pathway	0.60
Immune Checkpoint	therapeutic_target	pathway	0.60

Incoming (20)

Source	Relation	Type	Str
ADCY3	activates	gene	0.60
GDF15	expressed_in	gene	0.60
GDF15	associated_with	gene	0.60
GDF15	interacts_with	gene	0.60
IL-6	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
BDNF	associated_with	gene	0.60
AND	inhibits	gene	0.60
GLP1R	inhibits	gene	0.60
GDNF	inhibits	gene	0.60
GDNF	expressed_in	entity	0.60
GDNF	activates	gene	0.60
CYTOKINES	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
GDNF	interacts_with	gene	0.60
HDAC6	activates	gene	0.60
GDNF	regulates	gene	0.60
SHH	activates	gene	0.60
GDNF	associated_with	gene	0.50
BDNF	co_expressed_with	gene	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
GDF15-GFRAL Axis as Systemic Autophagy-Senescence Integrator	0.659	molecular biology	What is the optimal therapeutic window t

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GFRAL in their description or question text

No additional research found