BRD4

Understanding Entity Pages

This page aggregates everything SciDEX knows about BRD4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

BRD4 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, inhibits. Associated with Aging, Als, Cancer. Connected to 105 entities in the SciDEX knowledge graph.

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graph TD
    BRD4["BRD4"]
    H3K9["H3K9"]
    BRD4 -->|"modifies"| H3K9
    chromatin_remodeling(["chromatin_remodeling"])
    BRD4 -->|"regulates"| chromatin_remodeling
    neurodegeneration{"neurodegeneration"}
    BRD4 -->|"therapeutic target"| neurodegeneration
    Als{"Als"}
    BRD4 -->|"therapeutic target"| Als
    Aging{"Aging"}
    BRD4 -->|"therapeutic target"| Aging
    Ms{"Ms"}
    BRD4 -->|"therapeutic target"| Ms
    BRD4 -->|"activates"| Als
    Hepatitis{"Hepatitis"}
    BRD4 -->|"activates"| Hepatitis
    BRD4 -->|"activates"| Ms
    Lymphoma{"Lymphoma"}
    BRD4 -->|"associated with"| Lymphoma
    BRD4 -->|"biomarker for"| Ms
    Tumor{"Tumor"}
    BRD4 -->|"associated with"| Tumor
    h_addc0a61["h-addc0a61"]
    h_addc0a61 -->|"therapeutic target"| BRD4
    NSD3_short["NSD3-short"]
    NSD3_short -->|"binds"| BRD4
    SNORA28["SNORA28"]
    SNORA28 -->|"interacts with"| BRD4
    h_addc0a61 -->|"targets"| BRD4
    AMPK["AMPK"]
    AMPK -->|"associated with"| BRD4
    MITOPHAGY["MITOPHAGY"]
    MITOPHAGY -->|"activates"| BRD4
    FOXO3["FOXO3"]
    FOXO3 -->|"associated with"| BRD4
    ULK1["ULK1"]
    ULK1 -->|"associated with"| BRD4
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"associated with"| BRD4
    MTORC1["MTORC1"]
    MTORC1 -->|"associated with"| BRD4
    PYROPTOSIS["PYROPTOSIS"]
    PYROPTOSIS -->|"activates"| BRD4
    VDAC1["VDAC1"]
    VDAC1 -->|"inhibits"| BRD4
    style BRD4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

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