pathway

Drug Resistance

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Drug Resistance: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

364Connections

0Hypotheses

0Analyses

13Outgoing

50Incoming

0Experiments

0Debates

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🔀 Pathway Info

Name	Drug Resistance
Key Genes/Proteins	ABCB1, ABCG2, AGING, AKT, AKT1, ALZHEIMER
Related Diseases	Aging, Als, Alzheimer, Alzheimer'S Disease

Pathway Diagram

graph TD
    Drug_Resistance["Drug Resistance"]
    CANCER(["CANCER"])
    CANCER -->|"regulates"| Drug_Resistance
    Tumor{"Tumor"}
    Tumor -->|"regulates"| Drug_Resistance
    Cancer{"Cancer"}
    Cancer -->|"regulates"| Drug_Resistance
    style Drug_Resistance fill:#1a3a4a,stroke:#81c784,stroke-width:3px,color:#e0e0e0

Outgoing (13)

Target	Relation	Type	Str
CANCER	produces	disease	0.65
CANCER	targets	disease	0.65
STRESS GRANULES	associated_with	concept	0.50
Reactive Oxygen Species	associated_with	process	0.50
CENTRAL NERVOUS SYSTEM	inhibits	concept	0.50
PD-L1	inhibits	concept	0.50
PI3K/AKT/mTOR	activates	pathway	0.50
Myeloma	activates	disease	0.50
CISPLATIN	associated_with	drug	0.50
MTOR PATHWAY	associated_with	pathway	0.45
OSIMERTINIB	associated_with	drug	0.45
GEMCITABINE	associated_with	drug	0.45
PI3K/AKT/MTOR	associated_with	pathway	0.45

Incoming (351)

Source	Relation	Type	Str
Colorectal Cancer	therapeutic_target	disease	1.00
AUTOPHAGY	activates	gene	1.00
Cancer	activates	disease	1.00
Breast Cancer	therapeutic_target	disease	1.00
CANCER	activates	gene	1.00
APOPTOSIS	activates	gene	1.00
CANCER	regulates	gene	1.00
Cancer	regulates	disease	1.00
Cancer	therapeutic_target	disease	1.00
Tumor	therapeutic_target	disease	1.00
CANCER	therapeutic_target	gene	1.00
Tumor	activates	disease	1.00
PI3K	therapeutic_target	gene	1.00
BCL-2	therapeutic_target	gene	1.00
AKT	activates	gene	1.00
P53	therapeutic_target	gene	1.00
AKT	therapeutic_target	gene	1.00
OVERVIEW	therapeutic_target	gene	1.00
MTOR	therapeutic_target	gene	1.00
Als	therapeutic_target	disease	1.00
AUTOPHAGY	therapeutic_target	gene	1.00
Als	activates	disease	1.00
DNA	therapeutic_target	gene	1.00
GENES	therapeutic_target	gene	1.00
Tumor	regulates	disease	1.00
EGFR	therapeutic_target	gene	1.00
MIRNAS	therapeutic_target	gene	1.00
Carcinoma	therapeutic_target	disease	1.00
APOPTOSIS	therapeutic_target	gene	1.00
PI3K	activates	gene	1.00
Gastric Cancer	therapeutic_target	disease	1.00
Aging	therapeutic_target	disease	1.00
Lung Cancer	therapeutic_target	disease	1.00
Leukemia	therapeutic_target	disease	1.00
Stress Granules	promotes	process	0.95
AURKA	associated_with	gene	0.95
Protein Arginine Methyltransferases	involved_in	enzyme	0.92
Autophagy	associated_with	process	0.90
STAT3	promotes	protein	0.90
MTOR	promotes	protein	0.90
AKT	promotes	protein	0.90
Pi3K/Akt/Mtor Pathway	mediates	pathway	0.90
Survivin	promotes	protein	0.90
PI3K/AKT/mTOR	contributes_to	pathway	0.90
Survivin	mediates	protein	0.90
OVERVIEW	regulates	gene	0.90
ERK	therapeutic_target	gene	0.90
BCL2	therapeutic_target	gene	0.90
YB-3-17	suppresses	compound	0.88
Arginine Methylation	regulates	process	0.85

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning Drug Resistance in their description or question text

No additional research found