Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BRD3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | BRD3 |
| Full Name | Bromodomain-Containing Protein 3 |
| Chromosome | 9q34.2 |
| Function | encodes a member of the BET (Bromodomain and Extra-Terminal domain) family of chromatin readers, alongside BRD2, BRD4, and BRDT. |
| Amino Acids | 726 aa |
| UniProt ID | [Q15059](https://www.uniprot.org/uniprot/Q15059) |
| Ensembl ID | ENSG00000169925 |
| GeneCards | BRD3 |
| Human Protein Atlas | BRD3 |
| Bromodomains BD1 and BD2 | Tandem bromodomains that recognize acetylated histones (particularly H4K5ac, H4K8ac, H4K12ac, and H3K14ac) and acetylated non-histone proteins |
| Extra-terminal (ET) domain | Mediates protein–protein interactions with transcriptional co-regulators including NSD3, JMJD6, CHD4, and components of the ATAC and SWI/SNF chromatin remodeling complexes |
| SEED motif | Phosphorylation-dependent regulatory region |
| C-terminal domain (CTD) | Unlike BRD4, BRD3 lacks the extended CTD that mediates P-TEFb recruitment, giving it distinct functional roles |
| Transcriptional regulation | BRD3 promotes transcription from acetylated chromatin but does not directly recruit P-TEFb (unlike BRD4), instead facilitating RNA polymerase II passage through acetylated nucleosomal templates |
| Hematopoietic transcription | BRD3 has a specialized role in GATA1-dependent erythroid gene expression, directly binding acetylated GATA1 to maintain erythroid transcriptional programs |
| Associated Diseases | ALS |
| Interactions | BRD2, BRD4 |
| KG Connections | 5 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["BRD3"]
N1["ALS"]
N0 -->|"associated with"| N1
N2["BRD4"]
N0 -->|"co expressed with"| N2
N3["BRD2"]
N3 -->|"co expressed with"| N0
N4["neurodegeneration"]
N0 -->|"implicated in"| N4
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classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 disease
class N2 gene
class N3 geneHypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning BRD3 in their description or question text
No additional research found