Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about chromatin_remodeling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| SMC | regulates | cell_type | 0.64 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Chromatin Remodeling-Mediated Nutrient Sensing Restoration | 0.764 | neurodegeneration | Epigenetic reprogramming in aging neuron |
| Epigenetic Memory Reprogramming via CRISPRa-Mediated Chromat | 0.544 | neurodegeneration | CRISPR-based therapeutic approaches for |
| protective chromatin remodeling defines the therapeutic wind | 0.345 | neurodegeneration | Are DNA methylation changes in neurodege |
| protective chromatin remodeling defines the therapeutic wind | 0.326 | neurodegeneration | Are age-related DNA methylation changes |
Scientific analyses that reference this entity
epigenetics | 2026-04-10 | 0 hypotheses
neurodegeneration | 2026-04-10 | 0 hypotheses
neurodegeneration | 2026-04-10 | 7 hypotheses Top: 0.700
neurodegeneration | 2026-04-04 | 9 hypotheses Top: 0.779
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Acteoside treatment in LPS-induced SALI mouse model | validation | sepsis-associated acute lung i | 0.900 | 0.00 | LPS-induced SALI mouse model | proposed | N/A |
| Nrf2 inhibitor ML385 mechanism validation experiment | exploratory | sepsis-associated acute lung i | 0.850 | 0.00 | RAW264.7 cells and/or mouse mo | proposed | N/A |
| Acteoside effects on RAW264.7 macrophage cells | exploratory | sepsis-associated acute lung i | 0.850 | 0.00 | RAW264.7 cells | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745] | Yu CH, Davidson S, Harapas CR, Hilton JB | Cell | 2020 | 2 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| PARP1-DNA co-condensation drives DNA repair site assembly to prevent disjunction [PMID:38320550] | Chappidi, Quail, Doll, Vogel, Aleksandro | Cell | 2024 | 0 |
| DNA-Origami-Armored DNA Condensates. [PMID:39075031] | Yamashita, Sato, Suzuki, Ishikawa, Takin | Chembiochem : a European journ | 2024 | 0 |
| PARP1-DNA co-condensation drives DNA repair site assembly to prevent disjunction [PMID:38320550] | Chappidi Nagaraja; Quail Thomas; Doll Si | Cell | 2024 | 0 |
| DNA-Origami-Armored DNA Condensates. [PMID:39075031] | Unknown | Chembiochem : a European journ | 2024 | 0 |
| Regulation of Human DNA Primase-Polymerase PrimPol. [PMID:37758313] | Boldinova, Makarova | Biochemistry. Biokhimiia | 2023 | 0 |
| Global identification of SWI/SNF targets reveals compensation by EP400. [PMID:37922899] | Martin BJE, Ablondi EF, Goglia C | Cell | 2023 | 0 |
| Regulation of Human DNA Primase-Polymerase PrimPol. [PMID:37758313] | Unknown | Biochemistry. Biokhimiia | 2023 | 0 |
| Bone remodeling: an operational process ensuring survival and bone mechanical co [PMID:35851054] | Bolamperti Simona; Villa Isabella; Rubin | Bone research | 2022 | 0 |
| WDR45 contributes to neurodegeneration through regulation of ER homeostasis and [PMID:31204559] | ["Wan Huida", "Wang Qi", "Chen Xiuting", | Autophagy | 2020 | 0 |
| Mammalian SWI/SNF Chromatin Remodeling Complexes: Emerging Mechanisms and Therap [PMID:32873422] | Centore RC, Sandoval GJ, Soares LMM | Trends Genet | 2020 | 0 |
| TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745] | Yu CH, Davidson S, Harapas CR, Hilton JB | Cell | 2020 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| WDR45 contributes to neurodegeneration through regulation of ER homeostasis and [PMID:31204559] | ["Wan Huida", "Wang Qi", "Chen Xiuting", | Autophagy | 2020 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Homologous recombination and the repair of DNA double-strand breaks. [PMID:29599286] | Wright, Shah, Heyer | The Journal of biological chem | 2019 | 0 |
| Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-de [PMID:30643298] | Melamed Ze'ev; López-Erauskin Jone; | Nature neuroscience | 2019 | 0 |
| Homologous recombination and the repair of DNA double-strand breaks. [PMID:29599286] | Unknown | The Journal of biological chem | 2019 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.46 · 2026-04-27
closed · Rounds: 4 · Score: 0.46 · 2026-04-27
closed · Rounds: 4 · Score: 0.50 · 2026-04-21
closed · Rounds: 0 · Score: 0.48 · 2026-04-21
closed · Rounds: 0 · Score: 0.51 · 2026-04-21
closed · Rounds: 4 · Score: 0.73 · 2026-04-21
closed · Rounds: 0 · Score: 0.52 · 2026-04-21
closed · Rounds: 0 · Score: 0.58 · 2026-04-21
closed · Rounds: 4 · Score: 0.30 · 2026-04-21
closed · Rounds: 4 · Score: 0.95 · 2026-04-10
Hypotheses and analyses mentioning chromatin_remodeling in their description or question text
No additional research found