concept

FKBP5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FKBP5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

451Connections

0Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

3Debates

Summary

FKBP5 is a concept in neurodegeneration research. Key relationships include: associated with, interacts with, inhibits. Associated with ALS, Aging, Als. Connected to 195 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	FKBP5
Key Genes/Proteins	A2M, Actin, AGING, AKT, AKT1
Related Diseases	Addiction, Aging, Als, ALS, Alzheimer
Related Pathways	Akt

🔮 Predicted Structure: FKBP5 — AlphaFold Q13451 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Pathway Diagram

graph TD
    FKBP5["FKBP5"]
    FKBP5 -->|"inhibits"| Ms["Ms"]
    FKBP5 -->|"regulates"| Inflammation["Inflammation"]
    FKBP5 -->|"regulates"| Alzheimer["Alzheimer"]
    FKBP5 -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    FKBP5 -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    FKBP5 -->|"target for"| Als["Als"]
    FKBP5 -->|"interacts"| HSPA1A["HSPA1A"]
    SKA2["SKA2"] -->|"interacts"| FKBP5
    HSPA1A -->|"interacts"| FKBP5
    HSP90AA1["HSP90AA1"] -->|"interacts"| FKBP5
    DNAJB1["DNAJB1"] -->|"interacts"| FKBP5
    FKBP4["FKBP4"] -->|"interacts"| FKBP5
    CRH["CRH"] -->|"interacts"| FKBP5
    IL18["IL18"] -->|"activates"| FKBP5
    RAMP1["RAMP1"] -->|"inhibits"| FKBP5
    CRHR1["CRHR1"] -->|"interacts"| FKBP5
    GENES["GENES"] -->|"interacts"| FKBP5

Outgoing (278)

Target	Relation	Type	Str
Hpa Axis	involved_in	pathway	0.90
Emotional Aspects Of Tinnitus	involved_in	phenotype	0.90
secretory autophagy	promotes	process	0.88
Emotional Aspects of Tinnitus	contributes_to	phenotype	0.85
Emotional Aspects Of Tinnitus	contributes_to	phenotype	0.85
Secretory Autophagy	activates	process	0.85
PPAR-γ	regulates	transcription_factor	0.80
CeA	expressed_in	brain_region	0.80
glucocorticoid signaling	regulates	pathway	0.80
neural stem cells	activates	cell_type	0.80
NR3C1	associated_with	gene	0.80
HSP90	co_chaperone	protein	0.80
stress_induced_memory_loss	protective_against	phenotype	0.70
glucocorticoid_signaling	modulates	pathway	0.70
Autophagy	regulates	pathway	0.70
neurons	activates	cell_type	0.70
neural stem cells	regulates	cell_type	0.70
HSP90AA1	protein_interaction	gene	0.70
Neurodegeneration	interacts_with	disease	0.65
ALS	associated_with	disease	0.65
Hypertension	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Autoimmune	associated_with	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Ms	interacts_with	disease	0.65
Cancer	regulates	disease	0.65
Als	regulates	disease	0.65
Ptsd	associated_with	disease	0.65
Ms	inhibits	disease	0.65
Inflammation	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Depression	associated_with	disease	0.65
ALS	interacts_with	disease	0.65
Huntington	inhibits	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	activates	disease	0.65
Aging	inhibits	disease	0.65
Bipolar	associated_with	disease	0.65
Addiction	associated_with	disease	0.65
Inflammation	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Als	expressed_in	disease	0.65
Neuroinflammation	regulates	disease	0.65
Ptsd	inhibits	disease	0.65
Ms	regulates	disease	0.65
Schizophrenia	associated_with	disease	0.65
Als	associated_with	disease	0.65

Incoming (173)

Source	Relation	Type	Str
h-637a53c9	targets	hypothesis	0.90
Stress	upregulates	process	0.90
Central Amygdala	expressed_in	cell_type	0.85
Familiar Context Stress	upregulates	process	0.85
BDNF	associated_with	gene	0.80
SAFit compounds	targets	drug	0.70
SKA2	interacts_with	gene	0.64
HSP90AA1	interacts_with	gene	0.61
HSPA1A	interacts_with	gene	0.61
DNAJB1	interacts_with	gene	0.61
FKBP4	interacts_with	protein	0.60
CRH	associated_with	gene	0.60
MITOPHAGY	activates	gene	0.60
CRH	interacts_with	gene	0.60
IL18	activates	gene	0.60
RAMP1	inhibits	gene	0.60
HTR2A	associated_with	gene	0.60
DISC1	associated_with	gene	0.60
CRHR1	interacts_with	gene	0.60
TNF	associated_with	gene	0.60
NR3C1	interacts_with	gene	0.60
CRHR1	inhibits	gene	0.60
CALCA	inhibits	gene	0.60
BDNF	activates	gene	0.60
NR3C1	inhibits	gene	0.60
GRM4	associated_with	gene	0.60
TRPM2	associated_with	gene	0.60
DRD1	associated_with	gene	0.60
BMAL1	associated_with	gene	0.60
GABRA5	associated_with	gene	0.60
GRM3	associated_with	gene	0.60
DAO	associated_with	gene	0.60
NRG1	associated_with	gene	0.60
GRIN2B	associated_with	gene	0.60
RGS4	associated_with	gene	0.60
NCAM1	associated_with	gene	0.60
POLG	associated_with	gene	0.60
RAB7A	associated_with	gene	0.60
ARRB1	associated_with	gene	0.60
IL18BP	inhibits	gene	0.60
SYNGR1	associated_with	gene	0.60
TPH2	associated_with	gene	0.60
FKBP4	activates	gene	0.60
FKBP1A	interacts_with	gene	0.60
AND	associated_with	gene	0.60
LC3	inhibits	gene	0.60
PPAR-Γ	activates	gene	0.60
MYELIN	activates	gene	0.60
SNAP29	regulates	gene	0.60
ALZHEIMER	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (3)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning FKBP5 in their description or question text

No additional research found