protein

FKBP4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FKBP4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections
0Hypotheses
1Analyses
10Outgoing
5Incoming
0Experiments
1Debates

Summary

FKBP4 is a protein involved in neurodegeneration research. Key relationships include: associated with, activates, interacts with. Associated with Bipolar. Connected to 11 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolFKBP4
Chromosome5q35.3
Protein FamilyFKBP Family
Functionis an important component in the neurobiology of neurodegenerative diseases.
Subcellular LocalizationCytoplasm, Nucleus
Molecular Weight51.2 kDa
Amino Acids459 aa
UniProt ID[Q02790](https://www.uniprot.org/uniprot/Q02790)
GeneCardsFKBP4
Human Protein AtlasFKBP4
FKBP5Related immunophilin with higher immunosuppress
Associated DiseasesBipolar
InteractionsFKBP5, SKA2
KG Connections15 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

FKBP4 Protein

protein · 607 words

Pathway Diagram

graph TD
    FKBP4["FKBP4"]
    Bipolar{"Bipolar"}
    FKBP4 -->|"associated with"| Bipolar
    FKBP5["FKBP5"]
    FKBP4 -->|"interacts with"| FKBP5
    SKA2["SKA2"]
    FKBP4 -->|"activates"| SKA2
    GENES["GENES"]
    FKBP4 -->|"associated with"| GENES
    Cell_Cycle(["Cell Cycle"])
    FKBP4 -->|"associated with"| Cell_Cycle
    FKBP4 -->|"activates"| FKBP5
    Neuron["Neuron"]
    FKBP4 -->|"expressed in"| Neuron
    neurodegeneration["neurodegeneration"]
    FKBP4 -->|"implicated in"| neurodegeneration
    SKA2 -->|"interacts with"| FKBP4
    FKBP5 -->|"activates"| FKBP4
    AND["AND"]
    AND -->|"associated with"| FKBP4
    GENES -->|"associated with"| FKBP4
    style FKBP4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (10)

TargetRelationTypeStr
HSP90AA1protein_interactiongene0.70
Bipolarassociated_withdisease0.65
FKBP5interacts_withprotein0.60
FKBP5activatesgene0.60
ANDassociated_withgene0.60

Incoming (5)

SourceRelationTypeStr
SKA2interacts_withgene0.64
FKBP5activatesgene0.60
ANDassociated_withgene0.60
SKA2activatesgene0.60
GENESassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the minimal structural requirements for HSP70/HSP90 inhibitors to achie

drug discovery | 2026-04-09 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What are the minimal structural requirements for HSP70/HSP90 inhibitors to achie

closed · Rounds: 4 · Score: 0.86 · 2026-04-10

Related Research

Hypotheses and analyses mentioning FKBP4 in their description or question text

No additional research found