concept

EXOSOME

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EXOSOME: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

88Connections

8Hypotheses

0Analyses

44Outgoing

44Incoming

8Experiments

0Debates

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💡 Concept Info

Name	EXOSOME
Key Genes/Proteins	ADAM10, AKT, APOE, APP, BAX, BDNF
Related Diseases	AGING, ALS, ALZHEIMER, Alzheimer's disease, ALZHEIMER'S DISEASE

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Syntenin-1 Exosome Biogenesis Modulation Therapy for Neurodegeneration

idea · 1205 words

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Pathway Diagram

graph TD
    EXOSOME[EXOSOME]
    EXOSOME -->|interacts| Crispr[Crispr]
    EXOSOME -->|mediates| intercellular_communication[intercellular communication]
    EXOSOME -.biomarker for.-> Alzheimer_s_disease[Alzheimer's disease]
    EXOSOME -->|involved_in| Intercellular_Communication[Intercellular Communication]
    EXOSOME -->|activates| FOXO3[FOXO3]
    EXOSOME -->|regulates| TAU[TAU]
    EXOSOME -->|regulates| CELL_DEATH[CELL DEATH]
    EXOSOME -->|inhibits| LYSOSOMAL_DYSFUNCTION[LYSOSOMAL DYSFUNCTION]
    EXOSOME -->|regulates| MACROPHAGES[MACROPHAGES]
    EXOSOME -->|treats| CHOLESTEROL[CHOLESTEROL]
    multivesicular_endosome[multivesicular endosome] -->|involved_in| EXOSOME
    NTN1[NTN1] -->|component_of| EXOSOME
    TFEB[TFEB] -->|inhibits| EXOSOME
    METASTASIS[METASTASIS] -->|activates| EXOSOME

Outgoing (44)

Target	Relation	Type	Str
miR-522	associated_with	compound	0.90
Crispr	interacts_with	drug	0.85
Alzheimer's disease	biomarker_for	disease	0.80
intercellular communication	mediates	process	0.80
Intercellular Communication	involved_in	process	0.75
FOXO3	activates	gene	0.70
TAU	regulates	protein	0.70
CELL DEATH	regulates	phenotype	0.70
CHOLESTEROL	treats	phenotype	0.65
MACROPHAGES	regulates	cell_type	0.65
LYSOSOMAL DYSFUNCTION	inhibits	phenotype	0.65
VEGF	associated_with	gene	0.50
AGING	associated_with	phenotype	0.50
ALS	associated_with	disease	0.50
PRION	associated_with	protein	0.50
CORTEX	associated_with	brain_region	0.50
TDP-43	associated_with	gene	0.50
ADAM10	associated_with	gene	0.50
P-TAU	associated_with	protein	0.50
APOE	associated_with	gene	0.50
CD33	associated_with	gene	0.50
TNF	associated_with	gene	0.50
STAT3	associated_with	gene	0.50
PI3K	associated_with	gene	0.50
JAK2	associated_with	gene	0.50
MFN2	associated_with	gene	0.50
AKT	associated_with	gene	0.50
FOXO3	associated_with	gene	0.50
BAX	associated_with	gene	0.50
JNK	associated_with	gene	0.50
TREM2	associated_with	gene	0.50
TFEB	associated_with	gene	0.50
CX3CR1	associated_with	gene	0.50
GPX4	associated_with	gene	0.45
LRRK2	associated_with	gene	0.45
CSF	associated_with	phenotype	0.45
NLRP3	associated_with	gene	0.45
APP	associated_with	gene	0.45
S100B	associated_with	gene	0.45
ROS	associated_with	phenotype	0.45
TAU	associated_with	protein	0.45
CANCER	associated_with	disease	0.45
NEURON	associated_with	cell_type	0.45
BDNF	associated_with	gene	0.45

Incoming (44)

Source	Relation	Type	Str
Multivesicular Endosome	associated_with	cell_type	0.95
multivesicular endosome	involved_in	cell_type	0.95
NTN1	component_of	protein	0.90
TFEB	inhibits	gene	0.70
METASTASIS	activates	phenotype	0.65
MICROGLIAL ACTIVATION	associated_with	phenotype	0.50
NEURODEGENERATION	associated_with	phenotype	0.50
NEUROINFLAMMATION	associated_with	phenotype	0.50
TEMPORAL LOBE	associated_with	brain_region	0.50
PHAGOCYTOSIS	associated_with	phenotype	0.50
PARKINSON	associated_with	disease	0.50
CYTOKINES	associated_with	phenotype	0.50
DEMENTIA	associated_with	disease	0.50
LEWY BODY DEMENTIA	associated_with	disease	0.50
NEURONS	associated_with	cell_type	0.50
CYP46A1	associated_with	gene	0.50
CELL DEATH	associated_with	phenotype	0.50
APOPTOSIS	associated_with	phenotype	0.50
MICROGLIA	associated_with	cell_type	0.50
MONOCYTES	associated_with	cell_type	0.45
CHOLESTEROL	associated_with	phenotype	0.45
OBESITY	associated_with	disease	0.45
INFLAMMATION	associated_with	phenotype	0.45
CERAMIDE	associated_with	phenotype	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45
NLRP3 INFLAMMASOME	associated_with	pathway	0.45
TUMOR MICROENVIRONMENT	associated_with	phenotype	0.45
UBIQUITIN	associated_with	protein	0.45
HNRNPA1	associated_with	gene	0.45
PODOCYTES	associated_with	cell_type	0.45
AUTOPHAGY	associated_with	phenotype	0.45
HEPATOCELLULAR CARCINOMA	associated_with	disease	0.45
METASTASIS	associated_with	phenotype	0.45
LACTATE	associated_with	phenotype	0.45
LYSOSOMAL DYSFUNCTION	associated_with	phenotype	0.45
FIBROBLASTS	associated_with	cell_type	0.45
FERROPTOSIS	associated_with	phenotype	0.45
ALZHEIMER'S DISEASE	associated_with	disease	0.45
ALZHEIMER	associated_with	disease	0.45
ASTROCYTE	associated_with	cell_type	0.45
ENDOTHELIAL CELLS	associated_with	cell_type	0.45
MACROPHAGE	associated_with	cell_type	0.45
ISCHEMIA	associated_with	disease	0.45
MACROPHAGES	associated_with	cell_type	0.45

Targeting Hypotheses (8)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Plasma p-tau217-Triggered Exosome Dosing Maximizes lncRNA-00	0.938	molecular neurobiology	View
P2RX7-Mediated Exosome Secretion Blockade	0.807	neurodegeneration	Tau propagation mechanisms and therapeut
Microglial Exosome-Mediated Tau Propagation	0.702	neuroscience	Circuit-level neural dynamics in neurode
TNFRSF25-Mediated Aging Exosome Pathway Inhibition	0.587	neurodegeneration	Gene expression changes in aging mouse b
Gamma-Entrained PV Interneuron Networks Enable Precision p-t	0.536	molecular neurobiology	View

Gamma-Entrained PV Interneurons Enable Precision p-tau217-Gu	0.461	molecular neurobiology	View
CSF Neurofilament Light-Triggered Astrocyte-Derived Exosome	0.460	molecular neurobiology	View
Gamma-Entrained P-tau217 Biomarker Cascades Optimize lncRNA-	0.431	molecular neurobiology	View

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (8)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
P2rx7 genetic deletion in PS19 tauopathy mice	validation	Alzheimer's disease/tauopathy	0.900	PS19 tauopathy mice	proposed	N/A
P2rx7 congenic mouse model insulin tolerance testing	validation	insulin resistance	0.900	congenic mice (C57BL6 P2rx7 al	proposed	N/A
P2rx7 congenic mouse model glucose tolerance testing	validation	glucose intolerance	0.900	congenic mice (C57BL6 P2rx7 al	proposed	N/A
Single-cell RNA sequencing of mouse brains	exploratory	Alzheimer's disease/tauopathy	0.900	PS19 mouse brain tissue	proposed	N/A
P2RX7 variant rs1718119 association with glucose homeostasis in Botnia	exploratory	type 2 diabetes	0.900	human patients	proposed	N/A
Cell type-specific P2rx7 deletion in microglia vs astrocytes	validation	Alzheimer's disease/tauopathy	0.850	PS19 mice with cell type-speci	proposed	N/A
Brain-derived extracellular vesicles proteome analysis	exploratory	Alzheimer's disease/tauopathy	0.850	Brain-derived extracellular ve	proposed	N/A
BDEV injection and recipient microglial transcriptome analysis	validation	Alzheimer's disease/tauopathy	0.800	Recipient mice injected with B	proposed	N/A

Related Papers (4)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Death receptor 3: A paradoxical biomarker and therapeutic target in pan-cancer. [PMID:41605339]	Fang W, Du J, Xu Z, Liu Q, Liu Y et al.	Crit Rev Oncol Hematol	2026
Homocysteine as a biomarker in arthritis and depression: Evidence from NHANES an [PMID:41693749]	Deng C, He Z, Zhu X	SAGE Open Med	2026
The involvement of TNFRSF25 in age-related hearing loss. [PMID:41882185]	Roche MV, Tang PC, Yan D, De Marchena MR	Hum Genet	2026
Maternal immune activation perturbs intestinal niche through microbial glyceroph [PMID:41926285]	Chang H, Zhu X, Shen C, Xu X, Ni Y et al	Cell Rep	2026

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning EXOSOME in their description or question text

Gamma-Entrained PV Interneurons Enable Precision p-tau217-Guided lncRNA Exosome

Score: 0.461 · molecular neurobiology · 2026-04-21

## Mechanistic Overview Gamma-Entrained PV Interneurons Enable Precision p-tau217-Guided lncRNA Exosome Therapy in Early

CSF Neurofilament Light-Triggered Astrocyte-Derived Exosome Dosing Maximizes lnc

Score: 0.460 · molecular neurobiology · 2026-04-21

## Mechanistic Overview CSF Neurofilament Light-Triggered Astrocyte-Derived Exosome Dosing Maximizes lncRNA-0021 Therape

Gamma-Entrained P-tau217 Biomarker Cascades Optimize lncRNA-9969 Exosome Therapy

Score: 0.431 · molecular neurobiology · 2026-04-21

## Mechanistic Overview Gamma-Entrained P-tau217 Biomarker Cascades Optimize lncRNA-9969 Exosome Therapy Precision in Ea