concept

LEWY BODY DEMENTIA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LEWY BODY DEMENTIA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

72Connections

0Hypotheses

0Analyses

30Outgoing

42Incoming

0Experiments

0Debates

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💡 Concept Info

Name	LEWY BODY DEMENTIA
Key Genes/Proteins	AD, ADAM10, ALS, APOE, APP, AΒ
Related Diseases	ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS, CREUTZFELDT-JAKOB
Related Pathways	AUTOPHAGY

Pathway Diagram

graph TD
    LEWY_BODY_DEMENTIA[LEWY BODY DEMENTIA]
    LEWY_BODY_DEMENTIA -->|involves| oxidative_stress_response[oxidative stress response]
    Adaptive_Immune_System[Adaptive Immune System] -->|contributes to| LEWY_BODY_DEMENTIA
    PINK1[PINK1] -.prevents.-> LEWY_BODY_DEMENTIA
    pS65_Ub[pS65-Ub] -.biomarker for.-> LEWY_BODY_DEMENTIA
    T_Cell[T Cell] -->|involved_in| LEWY_BODY_DEMENTIA
    PHB2[PHB2] -->|interacts| LEWY_BODY_DEMENTIA

Outgoing (30)

Target	Relation	Type	Str
PROGRESSIVE SUPRANUCLEAR PALSY	regulates	disease	0.70
TAU	markers	gene	0.70
PROGRESSIVE SUPRANUCLEAR PALSY	markers	disease	0.70
NEURON	co_discussed	cell_type	0.60
PARKINSON'S DISEASE	associated_with	disease	0.60
PD	associated_with	gene	0.60
PARKINSON'S DISEASE	regulates	disease	0.60
PARKINSON'S DISEASE	causes	disease	0.60
PARKINSON'S DISEASE	activates	disease	0.60
PD	co_discussed	gene	0.60
PARKINSON'S DISEASE	co_discussed	disease	0.60
oxidative stress response	involves	pathway	0.55
TEMPORAL LOBE	associated_with	brain_region	0.50
TNF	associated_with	gene	0.50
APOE	associated_with	gene	0.50
APP	associated_with	gene	0.50
CYP46A1	associated_with	gene	0.50
EXOSOME	associated_with	organelle	0.50
CX3CR1	associated_with	gene	0.50
TDP-43	associated_with	gene	0.50
ADAM10	associated_with	gene	0.50
TREM2	associated_with	gene	0.50
CD33	associated_with	gene	0.50
TFEB	associated_with	gene	0.50
PINK1	associated_with	gene	0.45
STING	co_discussed	gene	0.40
SQSTM1	co_discussed	gene	0.40
MULTIPLE SCLEROSIS	co_discussed	disease	0.40
TAU	co_discussed	gene	0.40
PROGRESSIVE SUPRANUCLEAR PALSY	co_discussed	disease	0.40

Incoming (42)

Source	Relation	Type	Str
T Cell	involved_in	cell_type	0.90
Adaptive Immune System	contributes_to	process	0.90
PINK1	prevents	gene	0.90
pS65-Ub	biomarker_for	biomarker	0.90
APOE	associated_with	gene	0.80
GBA	associated_with	gene	0.80
APOE4	associated_with	gene	0.75
GRN	disrupts	gene	0.70
FTD	markers	disease	0.70
FTD	regulates	disease	0.70
AMYOTROPHIC LATERAL SCLEROSIS	mediates	disease	0.70
FRONTOTEMPORAL DEMENTIA	markers	disease	0.70
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	disease	0.70
SNCA	associated_with	protein	0.70
AD	co_discussed	gene	0.60
AΒ	co_discussed	gene	0.60
FRONTOTEMPORAL DEMENTIA	causes	disease	0.60
CJD	co_discussed	gene	0.60
FRONTOTEMPORAL DEMENTIA	regulates	disease	0.60
FRONTOTEMPORAL DEMENTIA	interacts_with	disease	0.60
FTD	interacts_with	disease	0.60
ALZHEIMER'S DISEASE	causes	disease	0.60
AD	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	disease	0.60
AUTOPHAGY	co_discussed	pathway	0.60
AD	causes	gene	0.60
GBA	regulates	gene	0.60
DLB	co_discussed	gene	0.60
ALZHEIMER'S DISEASE	co_discussed	disease	0.60
AD	markers	gene	0.60
ALZHEIMER'S DISEASE	markers	disease	0.60
ALS	interacts_with	gene	0.60
AD	disrupts	gene	0.60
PINK1	implicated_in	protein	0.60
PHB2	interacts_with	gene	0.55
APOE	co_discussed	gene	0.45
FRONTOTEMPORAL DEMENTIA	co_discussed	disease	0.45
FTD	co_discussed	disease	0.45
CREUTZFELDT-JAKOB	co_discussed	disease	0.40
CHOLINERGIC	co_discussed	cell_type	0.40
HUNTINGTON'S DISEASE	co_discussed	disease	0.40
AMYOTROPHIC LATERAL SCLEROSIS	co_discussed	disease	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LEWY BODY DEMENTIA in their description or question text

No additional research found