| Gene Symbol | VCP |
| Aliases | Valosin-Containing Protein |
| Chromosome | 9p13.3 |
| Function | of 806 amino acids with a molecular weight of approximately 97 kDa[@kobayashi2000] |
| Molecular Weight | 97 kDa |
| Amino Acids | 806 aa |
| Exons | 17 |
| Pathways | Er Stress |
| GeneCards | VCP |
| Human Protein Atlas | VCP |
| N-terminal domain (1-200 aa) | Contains the N/D1 linker and mediates cofactor binding. The N-domain itself adopts a double-psi beta barrel fold that interacts with various cofactors including UFD1-NPL4, p47, and UBXD proteins. |
| D1 ATPase domain (200-400 aa) | The first ATPase domain responsible for hexamer assembly. This domain forms the core of the ring structure and contributes to ATP-dependent conformational changes. |
| Associated Diseases | Als, Alzheimer, Amyotrophic Lateral Sclerosis, Dementia, Frontotemporal Dementia, Ms |
| Interactions | Actin, ALS, ALS-CAUSING MUTATIONS, AMYOTROPHIC LATERAL SCLEROSIS, AND, App |
| KG Connections | 214 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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