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protein 712 words KG: VALOSINCONTAININGPROTEIN
Contents

Valosin-Containing Protein (VCP)

🔬 Protein Info
Gene SymbolVALOSINCONTAININGPROTEIN
AliasesVALOSINCONTAININGPROTEIN
Function- Extracts ubiquitinated proteins from complexes
UFD1LUbiquitin recognition
NPL4Substrate delivery
p47Membrane trafficking
UBXD7/8Autophagy regulation
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (14)

VCP-Mediated Autophagy Enhancement
Score: 0.59Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76APOE-TREM2 Interaction Modulation
Score: 0.74Cross-Seeding Prevention Strategy
Score: 0.69TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69Glycine-Rich Domain Competitive Inhibition
Score: 0.64Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62TREM2-mediated microglial tau clearance enhancement
Score: 0.62TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58TREM2-Dependent Microglial Senescence Transition
Score: 0.54Cryptic Exon Silencing Restoration
Score: 0.53RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47

Related Analyses (7)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedTau propagation mechanisms and therapeutic interception poin
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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