Contents

VCP Protein (p97)

🔬 Protein Info

Gene Symbol	VCP
Aliases	VCPPROTEIN
Chromosome	9p13.3
Protein Family	AAA+ ATPase family
Protein Type	Enzyme
Target Class	Enzyme
Function	Small molecule inhibitors of VCP ATPase activity affecting protein quality control
Mechanism of Action	Small molecule inhibitors of VCP ATPase activity affecting protein quality control
Primary Expression	Ubiquitous - Brain, Muscle, Spinal cord
Subcellular Localization	Cytoplasm, nucleus, ER, mitochondria
Druggability	Medium (0.50)
Clinical Stage	Phase I
Molecular Weight	97 kDa
Amino Acids	806 aa
Exons	17
Pathways	Akt, Autophagy, Er Stress, Mitophagy, Ubiquitin-Proteasome
UniProt ID	P55072
Ensembl ID	ENSG00000165280
GeneCards	VCP
Human Protein Atlas	VCP
Associated Diseases	Als, Alzheimer, Alzheimer's Disease, AMI, amyotrophic lateral sclerosis
Known Drugs/Compounds	rapamycin, RAPAMYCIN
Interactions	Actin, AD, AKT, ALPHA-SYNUCLEIN, ALS, ALS-CAUSING MUTATIONS
SciDEX Target	View Target Profile (4 clinical trials)
SciDEX Hypotheses	VCP-Mediated Autophagy Enhancement VCP/p97 ATPase mutations impair extraction of ubiq VCP-Mediated Autophagy Enhancement
KG Connections	998 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

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