mechanism 2,601 words KG: ent-gene-9a7e7e49
Contents

VCP→TDP-43→ALS/FTD Causal Chain

🔬 Protein Info
Gene Symbolent-gene-9a7e7e49
FunctionVCP in Protein Quality Control
N-terminal domainAdapter protein binding, substrate recognition
D1 domainFirst ATPase domain, hexamer assembly
D2 domainSecond ATPase domain, major catalytic activity
C-terminal domainRegulatory, substrate interaction
KG Connections4 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (10)

Cryptic Exon Silencing Restoration
Score: 0.53
Axonal RNA Transport Reconstitution
Score: 0.70
Cross-Seeding Prevention Strategy
Score: 0.69
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
VCP-Mediated Autophagy Enhancement
Score: 0.57

Related Analyses (30)

RNA binding protein dysregulation across ALS FTD AD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (30)

Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40
Pre-Symptomatic Tau Detection in MAPT Mutation Carriers
clinical · proposed · Score: 0.40
Proteasome-Ubiquitin System Dysfunction Validation in Parkin
clinical · proposed · Score: 0.40
Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT
validation · proposed · Score: 0.40
C9orf72 Phenotype Divergence: ALS vs FTD Mechanism Study
clinical · proposed · Score: 0.40

Knowledge Graph (4 edges)

h-d4e73cf08f targets ent-gene-9a7e7e49
ent-gene-9a7e7e49 targeted_by h-d4e73cf08f
ent-gene-9a7e7e49 data_in benchmark_ot_ad_answer_key:VCP
benchmark_ot_ad_answer_key:VCP data_in ent-gene-9a7e7e49

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