Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ALS/FTD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| polyunsaturated fatty acids (PUFAs) | protects_against | compound | 1.00 |
| C9ORF72 | associated_with | gene | 0.95 |
| FBL | contributes_to | gene | 0.95 |
| TDP-43 Dysfunction | contributes_to | mechanism | 0.90 |
| VCP | risk_factor_for | gene | 0.90 |
| G4C2 Repeat Expansion | causes | biomarker | 0.90 |
| P53 | risk_factor_for | gene | 0.85 |
| RNA Condensates | contributes_to | process | 0.85 |
| Circadian Rhythm Disruption | associated_with | phenotype | 0.80 |
| FBL | contributes_to | protein | 0.80 |
| FBL | implicated_in | protein | 0.75 |
| C9ORF72 | causes | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Microglial AIM2 Inflammasome as the Primary Driver of TDP-43 | 0.824 | neurodegeneration | What are the mechanisms by which gut mic |
| C9orf72 ASO Treatment Reverses TDP-43 Pathology in ALS/FTD | 0.720 | neurodegeneration | Test Hypothesis Fixtures |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.720
neurodegeneration | 2026-04-06 | 7 hypotheses Top: 0.717
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiqui [PMID:30966861] | ["Han X", "Sun S", "Sun Y", "Song Q", "Z | Autophagy | 2020 | 1 |
| Inhibition of autophagy in microglia and macrophages exacerbates innate immune r [PMID:36652438] | Hegdekar N, Sarkar C, Bustos S, Ritzel R | Autophagy | 2023 | 0 |
| Inflammasome assembly in neurodegenerative diseases. [PMID:37633753] | Singh J, Habean ML, Panicker N | Trends in neurosciences | 2023 | 0 |
| NLRP3/caspase-1/GSDMD-mediated pyroptosis exerts a crucial role in astrocyte pat [PMID:34877938] | Li S, Sun Y, Song M, Song Y, Fang Y, Zha | JCI insight | 2021 | 0 |
| Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodeg [PMID:30381407] | Gordon R, Albornoz EA, Christie DC, Lang | Science translational medicine | 2018 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.75 · 2026-04-22
closed · Rounds: 4 · Score: 0.81 · 2026-04-16
Hypotheses and analyses mentioning ALS/FTD in their description or question text
No additional research found