protein

NPL4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NPL4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

29Connections

0Hypotheses

0Analyses

24Outgoing

5Incoming

0Experiments

0Debates

Summary

NPL4 protein - VCP cofactor, ERAD, ALS/FTD, protein quality control

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🔬 Protein Info

Gene Symbol	NPL4
Aliases	NPL4 protein
Function	NPL4 (nuclear protein localization 4 homolog) is a cofactor for VCP/p97 that forms a heterodimeric complex with UFD1. The UFD1-NPL4 complex recognizes ubiquitinated substrates and delivers them to ...
Subcellular Localization	4)</th></tr> <tr><td>Gene</td><td>NPLOC4</td></tr> <tr><td>UniP
Molecular Weight	68.6 kDa
Pathways	ubiquitin-proteasome, autophagy pathway
GeneCards	NPL4
Human Protein Atlas	NPL4
Associated Diseases	ALS, dementia, frontotemporal
Interactions	ATG14, LC3B, MAP1LC3B, PIK3C3, RPL26, RPN1
KG Connections	29 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

NPL4 Protein

protein · 626 words

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Pathway Diagram

graph TD
    NPL4(["NPL4"])
    style NPL4 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
    UBXD1["UBXD1"]
    UFD1(["UFD1"])
    VCP["VCP"]
    ubiquitin_proteasome(("ubiquitin-proteasome"))
    autophagy_pathway(("autophagy pathway"))

    NPL4 -->|"interacts_with"| UBXD1
    NPL4 -->|"interacts_with"| UFD1
    NPL4 -->|"interacts_with"| VCP
    NPL4 -->|"participates_in"| ubiquitin_proteasome
    NPL4 -->|"participates_in"| autophagy_pathway

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
    class UBXD1 gene
    class UFD1 protein
    class VCP gene
    class ubiquitin_proteasome pathway
    class autophagy_pathway pathway

Outgoing (24)

Target	Relation	Type	Str
VCP	regulates	gene	0.60
UFM1	activates	gene	0.60
UVRAG	activates	gene	0.60
VCP	activates	gene	0.60
ALS	activates	disease	0.60
frontotemporal dementia	activates	disease	0.60
oxidative stress response	participates_in	pathway	0.60
UBXD1	regulates	gene	0.60
ALS	associated_with	disease	0.60
dementia	associated_with	disease	0.60
frontotemporal	associated_with	disease	0.60
PIK3C3	activates	gene	0.60
RPL26	activates	gene	0.60
RPN1	activates	gene	0.60
SQSTM1	activates	gene	0.60
UFD1	activates	gene	0.60
UFL1	activates	gene	0.60
autophagy pathway	participates_in	pathway	0.55
VCP	interacts_with	gene	0.55
ubiquitin-proteasome	participates_in	pathway	0.55
UFD1	interacts_with	gene	0.55
UBXD1	interacts_with	gene	0.55
RPL26	co_expressed_with	gene	0.50
PIK3C3	co_expressed_with	gene	0.50

Incoming (5)

Source	Relation	Type	Str
ATG14	activates	gene	0.60
LC3B	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
LC3B	co_expressed_with	protein	0.50
MAP1LC3B	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NPL4 in their description or question text

No additional research found