gene

STAT3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STAT3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3672Connections

8Hypotheses

8Analyses

50Outgoing

50Incoming

0Experiments

11Debates

Summary

Signal Transducer and Activator of Transcription 3 - key transcription factor in neuroinflammation and neuronal survival

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🧬 Gene Info

Gene Symbol	STAT3
Full Name	Signal Transducer and Activator of Transcription 3
Chromosome	17q21.2
Protein Type	Transcription Factor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	92 kDa
Amino Acids	770 aa
Pathways	Akt, Amyloid, Angiogenesis, Apoptosis, Autophagy
UniProt ID	[P40763](https://www.uniprot.org/uniprot/P40763)
Ensembl ID	ENSG00000168610
GeneCards	STAT3
Human Protein Atlas	STAT3
Associated Diseases	acute lung injury, Aging, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	Acetyl-CoA, BARICITINIB, Benzo[a]pyrene, curcumin, Curcumin, dimethyl fumarate
Interactions	ABCG2, acetyl-CoA, ACETYL-COA, ACHE, ACSL4, Actin
SciDEX Hypotheses	Spinal Cord Astrocyte Reactivity Convergence
KG Connections	3620 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    STAT3["STAT3"] -->|"regulates"| MMP9["MMP9"]
    STAT3["STAT3"] -->|"regulates"| GFAP["GFAP"]
    STAT3["STAT3"] -->|"regulates"| MYC["MYC"]
    STAT3["STAT3"] -->|"regulates"| BCL2["BCL2"]
    STAT3["STAT3"] -->|"interacts"| Cancer["Cancer"]
    STAT3["STAT3"] -->|"interacts"| Als["Als"]
    JAK["JAK"] -->|"activates"| STAT3["STAT3"]
    GP130["GP130"] -->|"activates"| STAT3["STAT3"]
    TSPAN8["TSPAN8"] -->|"interacts"| STAT3["STAT3"]
    TRF33["TRF33"] -.->|"inhibits"| STAT3["STAT3"]
    style STAT3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (2068)

Target	Relation	Type	Str
ds-db4a006ea647	provides_data_for	dataset	1.00
Inflammation	inhibits	disease	1.00
GENES	therapeutic_target	gene	1.00
Alzheimer	activates	disease	1.00
Inflammation	associated_with	disease	1.00
Neurodegeneration	activates	disease	1.00
GENES	activates	gene	1.00
Immune Response	activates	pathway	1.00
MICROGLIA	activates	gene	1.00
Invasion	activates	pathway	1.00
GENES	associated_with	gene	1.00
INFLAMMATION	associated_with	gene	1.00
Autophagy	activates	pathway	1.00
Cancer	associated_with	disease	1.00
Tumor	regulates	disease	1.00
Inflammation	therapeutic_target	disease	1.00
Nf-Κb	activates	pathway	1.00
Als	regulates	disease	1.00
ASTROCYTES	activates	gene	1.00
Angiogenesis	activates	pathway	1.00
DNA	inhibits	gene	1.00
Nf-Κb	regulates	pathway	1.00
Als	treats	disease	1.00
Neuroinflammation	activates	disease	1.00
Cancer	regulates	disease	1.00
Als	inhibits	disease	1.00
Breast Cancer	therapeutic_target	disease	1.00
GENES	regulates	gene	1.00
IL-6	inhibits	gene	1.00
IL-6	activates	entity	1.00
Metastasis	therapeutic_target	pathway	1.00
Tumor	therapeutic_target	disease	1.00
CANCER	regulates	disease	1.00
TNF-Α	inhibits	gene	1.00
NEUROINFLAMMATION	activates	gene	1.00
Als	therapeutic_target	disease	1.00
JAK2	activates	gene	1.00
INFLAMMATION	therapeutic_target	gene	1.00
Inflammation	activates	disease	1.00
Aging	activates	disease	1.00
Jak-Stat	activates	pathway	1.00
CANCER	activates	disease	1.00
NF-ΚB	associated_with	gene	1.00
INFLAMMATION	activates	gene	1.00
CYTOKINES	activates	gene	1.00
Cancer	inhibits	disease	1.00
Tumor	treats	disease	1.00
Autoimmune	activates	disease	1.00
CANCER	therapeutic_target	gene	1.00
Cancer	therapeutic_target	disease	1.00

Incoming (1604)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	1.00
ds-db4a006ea647	data_in	dataset	1.00
APOPTOSIS	targets	gene	1.00
IL-6	associated_with	gene	1.00
APOPTOSIS	activates	gene	1.00
TNF	activates	gene	1.00
TNF	inhibits	gene	1.00
APOPTOSIS	regulates	gene	1.00
ROS	activates	gene	1.00
NEUROINFLAMMATION	associated_with	concept	0.98
CASP3	associated_with	gene	0.98
isoquercitrin	binds_to	drug	0.95
CASP3	activates	gene	0.95
Polyphyllin B	binds_to	drug	0.95
ILA	inhibits	drug	0.95
LEPTIN	activates	protein	0.95
CHI3L1	binds_to	protein	0.95
FYN	activates	gene	0.95
IL-6R	activates	protein	0.95
PHF2	regulates	enzyme	0.95
MN	downregulates	compound	0.95
LRWE	downregulates	compound	0.95
IPA	inhibits	compound	0.95
leptin signaling	activates	pathway	0.92
Cyclosporine A	upregulates	drug	0.92
TRIM32	inhibits	protein	0.90
NF-KB	associated_with	protein	0.90
Curcumin	inhibits	drug	0.90
FAK	activates	protein	0.90
JAK	phosphorylates	protein	0.90
PPP1CB	modifies	protein	0.90
JAK2	activates	protein	0.90
JAK	associated_with	gene	0.90
JAK2	phosphorylates	protein	0.90
ACETYL-COA	activates	gene	0.90
IL6	interacts_with	protein	0.90
JAK1	activates	protein	0.90
BRSK2	activates	protein	0.90
SBP	downregulates	drug	0.90
JAK	activates	protein	0.90
NF-KB	interacts_with	pathway	0.90
IL6	activates	protein	0.90
PKM2	phosphorylates	protein	0.90
TNF	therapeutic_target	gene	0.90
AKT1	targets	gene	0.90
ERK	activates	gene	0.90
PD-L1	binds_to	protein	0.89
S1PR1	phosphorylates	protein	0.88
OPN	activates	protein	0.88
SD36	inhibits	drug	0.88

Targeting Hypotheses (8)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
PDGF-BB/PDGFRβ/STAT3 Paracrine Signaling Axis Mediates Aβ-In	0.618	neurodegeneration	How do perivascular cells specifically r
Astrocytic SPP1 Modulation Through STAT3-Dependent Transcrip	0.551	neuroinflammation	What molecular mechanisms mediate SPP1-i
CNTF-JAK/STAT3 Reprogramming of Trained Microglia to Neuropr	0.547	neuroinflammation	What specific astrocyte-derived factors
Systemic IL-6–STAT3–Hepatic C3 Axis and BBB-Mediated Complem	0.540	neuroinflammation	How does sevoflurane-induced NF-κB activ
Astrocytic SPP1 Modulation via STAT3-Dependent Transcription	0.459	neuroinflammation	What molecular mechanisms mediate SPP1-i

Spinal Cord Astrocyte Reactivity Convergence	0.455	neuroinflammation	Why do clinical manifestations overlap d
RAGE/STAT3/IL-6 Autocrine Loop Mediates Aβ-Induced SPP1 Upre	0.442	neurodegeneration	How do perivascular cells specifically r
STAT3 Epigenetic Priming as Mechanism of Peripheral Cytokine	0.347	immunomics	Systemic immune profiling in neurodegene