gene 1,488 words KG: STAT3
Contents

STAT3 Gene

🧬 Gene Info
Gene SymbolSTAT3
Full NameSignal Transducer and Activator of Transcription 3
Chromosome17q21.2
Protein TypeTranscription Factor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight92 kDa
Amino Acids770 aa
PathwaysAkt, Amyloid, Angiogenesis, Apoptosis, Autophagy
UniProt ID[P40763](https://www.uniprot.org/uniprot/P40763)
Ensembl IDENSG00000168610
GeneCardsSTAT3
Human Protein AtlasSTAT3
Associated Diseasesacute lung injury, Aging, Als, Alzheimer, Alzheimer's disease
Known Drugs/CompoundsAcetyl-CoA, BARICITINIB, Benzo[a]pyrene, curcumin, Curcumin, dimethyl fumarate
InteractionsABCG2, acetyl-CoA, ACETYL-COA, ACHE, ACSL4, Actin
KG Connections3788 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (30)

Aquaporin-4 Polarization Rescue
Score: 0.73
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.85
CYP46A1 Overexpression Gene Therapy
Score: 0.92
SASP-Mediated Complement Cascade Amplification
Score: 0.91
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91

Related Analyses (20)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (2)

S-equol-induced ferroptosis mechanism in TNBC cells
exploratory · proposed · Score: 0.90
Proposed experiment from debate on Astrocytes adopt A1 (neur
falsification · proposed · Score: 0.40

See Also (6)

ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: therapeutic_target
ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: activates
ADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: regulates
AGO2 (Argonaute-2)
gene · KG edge: inhibits
AIFM1 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

IL6 activates STAT3
STAT3 activates VAV1
GPCR regulates STAT3
STAT3 regulates MITOCHONDRION
TSPAN8 interacts_with STAT3
STAT3 regulates MMP9
STAT3 regulates MYC
STAT3 regulates BCL2
TRF33 inhibits STAT3
STAT3 activates GASTRIC_CANCER

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