SciDEX — LEPTIN

graph TD
    LEPTIN["LEPTIN"]
    LEPTIN -->|"regulates"| Food_Intake["Food Intake"]
    LEPTIN -->|"treats"| Paqr4_Induced_Metabolic_Defect["Paqr4-Induced Metabolic Defects"]
    LEPTIN -->|"treats"| Hyperglycemia["Hyperglycemia"]
    LEPTIN -->|"treats"| Hyperglycaemia["Hyperglycaemia"]
    LEPTIN -->|"regulates"| Aging["Aging"]
    LEPTIN -->|"regulates"| Diabetes["Diabetes"]
    LEPTIN -->|"regulates"| Obesity["Obesity"]
    LEPTIN -->|"interacts"| Als["Als"]
    PAQR4["PAQR4"] -->|"activates"| LEPTIN
    CERS2["CERS2"] -->|"regulates"| LEPTIN
    AGING["AGING"] -->|"regulates"| LEPTIN
    ARC["ARC"] -->|"interacts"| LEPTIN
    CRH["CRH"] -->|"regulates"| LEPTIN
    POMC["POMC"] -->|"regulates"| LEPTIN
    NPY["NPY"] -->|"regulates"| LEPTIN
    NTS["NTS"] -->|"interacts"| LEPTIN

Outgoing (43)

Target	Relation	Type	Str
STAT3	activates	protein	0.95
Dopaminergic Neurodegeneration	protects_against	process	0.90
Food Intake	regulates	process	0.90
Substantia Nigra	expressed_in	brain_region	0.90
Paqr4-Induced Metabolic Defects	treats	phenotype	0.85
Neuroinflammation	modulates	process	0.85
Oxidative Stress	modulates	process	0.85
ABETA	regulates	protein	0.80
Synaptic Plasticity	associated_with	process	0.80
Hyperglycemia	treats	phenotype	0.75
Hyperglycaemia	treats	phenotype	0.75
ABETA	inhibits	protein	0.70
Chronic Pain	associated_with	disease	0.60
Obesity	regulates	disease	0.60
Aging	regulates	disease	0.60
Diabetes	regulates	disease	0.60
Obesity	therapeutic_target	disease	0.60
Neuroinflammation	activates	disease	0.60
Diabetes	activates	disease	0.60
Cardiomyopathy	therapeutic_target	disease	0.60
Als	interacts_with	disease	0.60
Aging	biomarker_for	disease	0.60
Neurodegeneration	regulates	disease	0.60
Als	regulates	disease	0.60
Anxiety	regulates	disease	0.60
Fibrosis	biomarker_for	disease	0.60
Als	activates	disease	0.60
Alzheimer	regulates	disease	0.60
Senescence	biomarker_for	disease	0.60
Obesity	activates	disease	0.60
Obesity	inhibits	disease	0.60
Als	biomarker_for	disease	0.60
Diabetes	therapeutic_target	disease	0.60
Alzheimer	activates	disease	0.60
Neurodegeneration	activates	disease	0.60
Als	therapeutic_target	disease	0.60
Ubiquitin-Proteasome	therapeutic_target	pathway	0.55
Apoptosis	biomarker_for	pathway	0.55
Blood-Brain Barrier	regulates	pathway	0.55
Cholesterol	inhibits	pathway	0.55
Lipid Metabolism	inhibits	pathway	0.55
Synaptic Plasticity	activates	pathway	0.55
Phagocytosis	activates	pathway	0.55

Incoming (56)

Source	Relation	Type	Str
PAQR4	activates	gene	0.60
AGING	regulates	gene	0.60
MITOCHONDRIA	biomarker_for	gene	0.60
PGRN	activates	gene	0.60
AMYLOID	biomarker_for	gene	0.60
IL-6	activates	gene	0.60
GHRL	biomarker_for	gene	0.60
APOPTOSIS	biomarker_for	gene	0.60
IGF-1	biomarker_for	gene	0.60
B4GALNT1	regulates	gene	0.60
AMYLOID	inhibits	gene	0.60
ALZHEIMER	regulates	gene	0.60
PTP1B	expressed_in	gene	0.60
ALZHEIMER	activates	gene	0.60
MITOCHONDRIA	therapeutic_target	gene	0.60
CERS2	regulates	gene	0.60
ARC	interacts_with	gene	0.60
CRH	regulates	gene	0.60
POMC	regulates	gene	0.60
NPY	regulates	gene	0.60
NTS	interacts_with	gene	0.60
VIM	activates	gene	0.60
PROGRANULIN	activates	gene	0.60
VIMENTIN	activates	gene	0.60
TGM2	biomarker_for	gene	0.60
FGF21	activates	gene	0.60
CX3CL1	activates	gene	0.60
HMGB1	biomarker_for	gene	0.60
PLAU	activates	gene	0.60
JUN	regulates	gene	0.60
ST8SIA1	associated_with	gene	0.60
TNFRSF1B	associated_with	gene	0.60
TNF	associated_with	gene	0.60
UROCORTIN	interacts_with	gene	0.60
ANGPT1	activates	gene	0.60
SP1	inhibits	gene	0.60
DKK1	inhibits	gene	0.60
STAT3	inhibits	gene	0.60
NESTIN	inhibits	gene	0.60
C1Q	activates	gene	0.60
CD68	activates	gene	0.60
BDNF	expressed_in	gene	0.60
PPAR	therapeutic_target	gene	0.60
S100B	biomarker_for	gene	0.60
GPNMB	biomarker_for	gene	0.60
APP	biomarker_for	gene	0.60
BDNF	activates	gene	0.60
FGF23	activates	gene	0.60
CXCL10	activates	gene	0.60
FNDC5	activates	gene	0.60

Targeting Hypotheses (0)

Mentioning Analyses (0)

Experiments (0)

Name	LEPTIN
Key Genes/Proteins	ABETA, STAT3

LEPTIN

Understanding Entity Pages

Pathway Diagram

Outgoing (43)

Incoming (56)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Experiments (0)

Related Papers (0)

Debates (0)

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