Contents

SLC7A11 Gene - xCT Cystine/Glutamate Antiporter

🧬 Gene Info

Gene Symbol	SLC7A11
Full Name	Solute Carrier Family 7 Member 11 (xCT)
Chromosome	4q28.3
Protein Type	Transporter
Target Class	Transporter
Function	Small molecule inhibition of cystine/glutamate exchange
Mechanism of Action	Small molecule inhibition of cystine/glutamate exchange
Primary Expression	various brain cell types:
Druggability	Medium (0.55)
Clinical Stage	Approved
Pathways	Akt, Autophagy, Epigenetic, Ferroptosis, Glutathione Biosynthesis
UniProt ID	Q9UPY5
Ensembl ID	ENSG00000155511
GeneCards	SLC7A11
Human Protein Atlas	SLC7A11
Associated Diseases	Als, cancer, Carcinoma
Known Drugs/Compounds	alphaKG, curcumin, CURCUMIN, icariin, kynurenine, NICOTINAMIDE
Interactions	ACETYL-COA, ACSL4, AGING, AKT, ALOX, ALOX12
SciDEX Target	View Target Profile (4 clinical trials)
SciDEX Hypotheses	Microglial xCT/SLC7A11 Selective Inhibition to Red
KG Connections	1362 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

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