gene 2,670 words KG: RHOA
Contents

RHOA Gene — Ras Homolog Family Member A

🧬 Gene Info
Gene SymbolRHOA
Full NameRas Homolog Family Member A
Chromosome3p21.31
Functionencodes a small GTP-binding protein that functions as a molecular switch, cycling between an active GTP-bound state and an inactive GDP-bound state.
Molecular Weight~22 kDa
Amino Acids191 aa
PathwaysAkt, Angiogenesis, Apoptosis, Complement, Egfr Signaling
UniProt ID[P61586](https://www.uniprot.org/uniprotkb/P61586/entry)
Ensembl IDENSG00000167553
GeneCardsRHOA
Human Protein AtlasRHOA
Associated DiseasesAlzheimer, cancer, Dementia, Lung Cancer, Ms, neurodevelopmental disorders
InteractionsACVR1, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYLOID-BETA
KG Connections354 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (17)

Microglial Purinergic Reprogramming
Score: 0.70
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68
Complement C1q Subtype Switching
Score: 0.66
Ephrin-B2/EphB4 Axis Manipulation
Score: 0.64
Netrin-1 Gradient Restoration
Score: 0.59
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Complement C1q Mimetic Decoy Therapy
Score: 0.69
Extracellular Matrix Stiffness Modulation
Score: 0.69
Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69
Lysosomal Positioning Dynamics Modulation
Score: 0.69
Synthetic Biology Rewiring via Orthogonal Receptors
Score: 0.65
Transglutaminase-2 Cross-Linking Inhibition Strategy
Score: 0.64
Quantum Coherence Disruption in Cellular Communication
Score: 0.63
Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics
Score: 0.62
Temporal Decoupling via Circadian Clock Reset
Score: 0.54

Related Analyses (7)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (8)

Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: inhibits
ACTB Gene
gene · KG edge: associated_with
ACVR1 Gene
gene · KG edge: interacts_with
ARF1 Gene
gene · KG edge: activates
ARHGEF2 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

EPHB4 activates RHOA
RHOA inhibits ARF1
ARF1 inhibits RHOA
P62 regulates RHOA
ROCK1 activates RHOA
LAMP1 regulates RHOA
SQSTM1 regulates RHOA
RHOA regulates TFEB
RHOA regulates APP
RHOA regulates SQSTM1

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