concept

INSULIN RESISTANCE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about INSULIN RESISTANCE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1951Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

INSULIN RESISTANCE is a concept in neurodegeneration research. Key relationships include: activates, therapeutic target, inhibits. Associated with ALS, Aging, Als. Connected to 852 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	INSULIN RESISTANCE
Key Genes/Proteins	6-OHDA, ACSL4, AGING, AKT, AKT1, ALOX15
Related Diseases	Aging, Als, ALS, Alzheimer
Related Pathways	Akt

Pathway Diagram

graph TD
    INSULIN_RESISTANCE["INSULIN RESISTANCE"]
    INSULIN_RESISTANCE -->|"inhibits"| PI3K_Akt_mTOR_pathway["PI3K/Akt/mTOR pathway"]
    INSULIN_RESISTANCE -->|"contributes to"| AGEs["AGEs"]
    INSULIN_RESISTANCE -->|"causes"| neurodegeneration["neurodegeneration"]
    INSULIN_RESISTANCE -->|"activates"| Parkinson_s_disease["Parkinson's disease"]
    INSULIN_RESISTANCE -->|"activates"| Alzheimer_s_disease["Alzheimer's disease"]
    INSULIN_RESISTANCE -->|"activates"| brain_aging["brain aging"]
    INSULIN_RESISTANCE -->|"target for"| Carcinoma["Carcinoma"]
    PI3K_Akt_mTOR_pathway -->|"causes"| INSULIN_RESISTANCE
    lycorine["lycorine"] -->|"treats"| INSULIN_RESISTANCE
    resveratrol["resveratrol"] -.protects against.-> INSULIN_RESISTANCE
    Tirzepatide["Tirzepatide"] -.protects against.-> INSULIN_RESISTANCE
    SCP_oil["SCP-oil"] -->|"inhibits"| INSULIN_RESISTANCE
    PI3K_AKT_pathway["PI3K/AKT pathway"] -->|"regulates"| INSULIN_RESISTANCE

Outgoing (1025)

Target	Relation	Type	Str
Fatty Liver	activates	disease	1.00
OXIDATIVE STRESS	activates	gene	1.00
Insulin Resistance	associated_with	disease	1.00
Inflammation	activates	disease	1.00
Hypertension	associated_with	disease	1.00
Diabetes	therapeutic_target	disease	1.00
Insulin Resistance	inhibits	disease	1.00
Als	therapeutic_target	disease	1.00
Oxidative Stress	activates	pathway	1.00
Type 2 Diabetes	therapeutic_target	disease	1.00
INFLAMMATION	activates	gene	1.00
Insulin Resistance	therapeutic_target	disease	1.00
EXERCISE	activates	gene	1.00
Inflammation	associated_with	disease	1.00
Diabetes	activates	disease	1.00
Type 2 Diabetes	activates	disease	1.00
ALZHEIMER	activates	gene	1.00
Metabolic Syndrome	activates	disease	1.00
Als	associated_with	disease	1.00
Insulin Resistance	activates	disease	1.00
Insulin Signaling	activates	pathway	1.00
Als	regulates	disease	1.00
Diabetes	regulates	disease	1.00
Metabolic Syndrome	associated_with	disease	1.00
Lipid Metabolism	activates	pathway	1.00
Type 2 Diabetes	associated_with	disease	1.00
Alzheimer	activates	disease	1.00
Obesity	activates	disease	1.00
PI3K	activates	gene	1.00
Obesity	associated_with	disease	1.00
Oxidative Stress	activates	pathway	1.00
Inflammation	therapeutic_target	disease	1.00
Diabetes	associated_with	disease	1.00
Als	activates	disease	1.00
AMPK	activates	gene	1.00
Nf-Κb	activates	pathway	1.00
Insulin Signaling	activates	pathway	1.00
Lipid Metabolism	activates	pathway	1.00
ALZHEIMER'S DISEASE	activates	gene	1.00
Oxidative Stress	associated_with	pathway	1.00
Insulin Resistance	causes	disease	0.95
Inflammation	treats	disease	0.95
Inflammation	regulates	disease	0.95
Obesity	inhibits	disease	0.95
Fatty Liver	therapeutic_target	disease	0.95
Als	inhibits	disease	0.95
Type 2 Diabetes	regulates	disease	0.95
sarcopenia	causes	phenotype	0.95
Als	treats	disease	0.95
Aging	therapeutic_target	disease	0.95

Incoming (926)

Source	Relation	Type	Str
Obesity	associated_with	disease	1.00
Als	activates	disease	1.00
Type 2 Diabetes	associated_with	disease	1.00
ROS	activates	gene	1.00
Als	regulates	disease	1.00
OXIDATIVE STRESS	activates	gene	1.00
Metabolic Syndrome	associated_with	disease	1.00
INSULIN RESISTANCE	inhibits	gene	1.00
DIABETES MELLITUS	associated_with	gene	1.00
Diabetes	associated_with	disease	1.00
Type 2 Diabetes	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
Hypertension	associated_with	disease	1.00
INFLAMMATION	therapeutic_target	gene	1.00
PI3K	activates	gene	1.00
Diabetes	therapeutic_target	disease	1.00
INSULIN RESISTANCE	associated_with	gene	1.00
AMPK	activates	gene	1.00
INSULIN RESISTANCE	activates	gene	1.00
INSULIN RESISTANCE	therapeutic_target	gene	1.00
Obesity	activates	disease	1.00
Inflammation	activates	disease	1.00
INFLAMMATION	associated_with	gene	1.00
Als	associated_with	disease	1.00
INFLAMMATION	activates	gene	1.00
Diabetes	activates	disease	1.00
Inflammation	associated_with	disease	1.00
EXERCISE	activates	gene	1.00
ALZHEIMER'S DISEASE	activates	gene	1.00
ALZHEIMER	activates	gene	1.00
ROS	activates	gene	1.00
INFLAMMATION	activates	gene	1.00
Type 2 Diabetes Mellitus	associated_with	disease	0.95
MITOPHAGY	activates	gene	0.95
Inflammation	therapeutic_target	disease	0.95
CYTOKINES	activates	gene	0.95
DIABETES MELLITUS	activates	gene	0.95
AKT	activates	gene	0.95
AUTOPHAGY	activates	gene	0.95
Alzheimer	activates	disease	0.95
APOPTOSIS	associated_with	gene	0.95
MITOCHONDRIA	associated_with	gene	0.95
Type 2 Diabetes	activates	disease	0.95
ALZHEIMER	therapeutic_target	gene	0.95
DIABETES MELLITUS	therapeutic_target	gene	0.95
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.95
Type 2 Diabetes Mellitus	causes	disease	0.95
OXIDATIVE STRESS	associated_with	gene	0.95
PI3K/Akt/mTOR pathway	regulates	pathway	0.95
INFLAMMATION	treats	gene	0.95

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Brain Insulin Resistance with Glucose Transporter Dysfunctio	0.596	neurodegeneration	Metabolic reprogramming in neurodegenera
Brain Insulin Resistance and Metabolic Dysregulation	0.480	neurodegeneration	Cross-disease neurodegeneration mechanis

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (9)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Comparative study of the glucolipid profile and GLUTs gene expression in respons [PMID:41232212]	["Wang Z", "Wang H", "Du P", "Zhang X",	Poultry science	2025
Altered Glut4, IRAP, and Brain Insulin Signaling in a Mouse Model of Epilepsy an [PMID:41369048]	["Xu W", "Neal E", "Barlow N", "Thompson	Journal of neurochemistry	2025
Targeting glucose transporters in parkinson's disease: a novel metabolic approac [PMID:40879857]	["Singh G", "Ansari S", "Aran K"]	Metabolic brain disease	2025
Tirzepatide prevents neurodegeneration through multiple molecular pathways. [PMID:38287296]	Fontanella RA, Ghosh P, Pesapane A, Takt	Journal of translational medic	2024
A high fat diet potentiates neonatal iron overload-induced memory impairments in [PMID:38358514]	["do Nascimento F", "de Freitas B", "Dos	European journal of nutrition	2024
[WALANT - Wide Awake Local Anaesthesia No Tourniquet: Complications in elective [PMID:35168268]	Wieschollek S, Forster S, Megerle K	Handchirurgie, Mikrochirurgie,	2022
Complete Genome Sequence of Geobacter sp. Strain FeAm09, a Moderately Acidophili [PMID:33446582]	Yadav P, Antony-Babu S, Hayes E, Healy O	Microbiology resource announce	2021
Engineering complex communities by directed evolution. [PMID:33986540]	Chang CY, Vila JCC, Bender M, Li R, Mank	Nature ecology & evolution	2021
Successful Nonoperative Treatment of Osteochondritis Dissecans of the Humeral Ca [PMID:34825100]	Tajika T, Kuboi T, Endo F, Hatori Y, Sai	Progress in rehabilitation med	2021

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning INSULIN RESISTANCE in their description or question text

No additional research found