gene

PIK3CA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PIK3CA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

725Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

PIK3CA is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, associated with, interacts with. Associated with Aging, Als, Amyotrophic Lateral Sclerosis. Connected to 338 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PIK3CA
Chromosome	3q26.32
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	120 kDa
Amino Acids	068 aa
Exons	21
Pathways	PI3K, mTOR
GeneCards	PIK3CA
Human Protein Atlas	PIK3CA
Adaptor-binding domain (ABD)	Residues 1-108, mediates interaction with p85 regulatory subunit
C2 domain	Residues 170-270, membrane targeting and lipid binding
Helical domain	Residues 330-600, regulatory interactions
Kinase domain	Residues 700-1068, catalytic activity (phosphoinositide 3-kinase)
Associated Diseases	Aging, Als, Breast cancer
Known Drugs/Compounds	Alpelisib, Apitolisib, Chrysotoxine, Paxalisib, rapamycin
Interactions	ACVR1, AKT, AKT1, AKT3, APOPTOSIS, App
KG Connections	724 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PIK3CA Gene

gene · 891 words

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Pathway Diagram

graph TD
    PIK3CA["PIK3CA"]
    PIK3CA -->|"causes"| ESCC["ESCC"]
    PIK3CA -->|"activates"| MTOR["MTOR"]
    PIK3CA -->|"activates"| mTOR["mTOR"]
    PIK3CA -->|"target for"| Heart_Failure["Heart Failure"]
    PIK3CA -->|"target for"| Ms["Ms"]
    PIK3CA -->|"regulates"| Cancer["Cancer"]
    PIK3CA -->|"inhibits"| Tumor["Tumor"]
    PIK3CA -->|"target for"| Carcinoma["Carcinoma"]
    PI3K["PI3K"] -->|"regulates"| PIK3CA
    MDM2["MDM2"] -->|"regulates"| PIK3CA

Outgoing (456)

Target	Relation	Type	Str
Cancer	associated_with	disease	1.00
Tumor	associated_with	disease	1.00
Als	therapeutic_target	disease	1.00
Cancer	therapeutic_target	disease	1.00
Tumor	therapeutic_target	disease	1.00
AKT	therapeutic_target	gene	1.00
Pi3K/Akt/Mtor Pathway	associated_with	pathway	0.95
Diffuse Intrinsic Pontine Glioma	associated_with	disease	0.95
AKT	associated_with	protein	0.95
AKT1	activates	protein	0.95
Pi3K-Akt-Mtor Pathway	activates	pathway	0.95
PI3K-Akt-mTOR Pathway	activates	pathway	0.90
ESCC	causes	disease	0.90
PI3K	encodes	protein	0.90
PI3K-AKT-mTOR signaling	participates_in	pathway	0.90
Pi3K/Akt	inhibits	pathway	0.90
PI3K/AKT/mTOR	activates	pathway	0.85
Aging	therapeutic_target	disease	0.85
Als	associated_with	disease	0.85
Breast Cancer	therapeutic_target	disease	0.85
Bladder Cancer Metabolism	regulates	phenotype	0.85
Tumor	inhibits	disease	0.85
Cancer	inhibits	disease	0.85
niche formation	activates	process	0.85
HIF1A	activates	gene	0.82
MAPK signaling	participates_in	pathway	0.80
fibrinogen receptor activation	associated_with	process	0.80
Vascular Niche Formation	involved_in	process	0.80
Chrysotoxine	interacts_with	compound	0.80
cell proliferation	promotes	process	0.80
Breast cancer	causes	disease	0.80
MTOR	activates	protein	0.80
Pi3K/Akt	therapeutic_target	pathway	0.80
AKT	inhibits	gene	0.80
Trastuzumab Deruxtecan	associated_with	drug	0.75
Cancer	regulates	disease	0.75
Breast Cancer	inhibits	disease	0.75
Carcinoma	therapeutic_target	disease	0.75
Cancer	interacts_with	disease	0.75
Colorectal Cancer	inhibits	disease	0.75
Als	inhibits	disease	0.75
Inflammation	therapeutic_target	disease	0.75
AKT	interacts_with	gene	0.70
Mtor	therapeutic_target	pathway	0.70
MTOR	therapeutic_target	gene	0.70
MTOR	associated_with	gene	0.70
Mtor	associated_with	pathway	0.70
Oxidative Stress	therapeutic_target	pathway	0.70
mTOR	activates	protein	0.70
Mtor	inhibits	pathway	0.70

Incoming (269)

Source	Relation	Type	Str
CANCER	therapeutic_target	gene	1.00
PI3K	inhibits	gene	1.00
Alpelisib	inhibits	drug	0.95
Paxalisib	inhibits	drug	0.90
KRAS	associated_with	gene	0.90
PI3K	targets	gene	0.90
CANCER	associated_with	gene	0.90
RLN	phosphorylates	protein	0.85
P2Ry12	activates	protein	0.85
Apitolisib	inhibits	drug	0.85
Chrysotoxine	targets	compound	0.80
PTEN	therapeutic_target	gene	0.80
CANCER	inhibits	gene	0.80
IGF1R	interacts_with	gene	0.70
ARID1A	associated_with	gene	0.70
GENES	associated_with	gene	0.70
OXIDATIVE STRESS	therapeutic_target	gene	0.70
JAK2	targets	gene	0.70
PTEN	associated_with	gene	0.70
CLCN8	associated_with	gene	0.70
TP53	therapeutic_target	gene	0.70
MAPK1	targets	gene	0.70
EGFR	targets	gene	0.70
APC	associated_with	gene	0.70
MAPK1	associated_with	gene	0.70
TP53	associated_with	gene	0.70
PI3K	associated_with	gene	0.70
PI3K	treats	gene	0.70
PTEN	inhibits	gene	0.70
APOPTOSIS	therapeutic_target	gene	0.70
PI3K	activates	gene	0.70
MTOR PATHWAY	regulates	pathway	0.65
AKT	associated_with	gene	0.60
MTOR	inhibits	gene	0.60
AKT1	associated_with	gene	0.60
RAS	associated_with	gene	0.60
BRCA1	therapeutic_target	gene	0.60
PALB2	therapeutic_target	gene	0.60
GATA2	therapeutic_target	gene	0.60
BAX	inhibits	gene	0.60
BCL2	inhibits	gene	0.60
IGF2	inhibits	gene	0.60
TSC1	associated_with	gene	0.60
TPR	therapeutic_target	gene	0.60
RB1	therapeutic_target	gene	0.60
PCDH15	therapeutic_target	gene	0.60
NF1	therapeutic_target	gene	0.60
NF2	therapeutic_target	gene	0.60
BRAF	interacts_with	gene	0.60
NF1	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PIK3CA in their description or question text

No additional research found