concept

MTOR PATHWAY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MTOR PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

215Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

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💡 Concept Info

Name	MTOR PATHWAY
Key Genes/Proteins	ACSL4, AKT, AMPK, AMYLOID, APOE, APP
Related Diseases	AGING, ALZHEIMER'S DISEASE, AUTOPHAGY, BREAST CANCER

Pathway Diagram

graph TD
    MTOR_PATHWAY["MTOR PATHWAY"]
    MTOR_PATHWAY -->|"inhibits"| autophagy["autophagy"]
    MTOR_PATHWAY -->|"mediates"| Offspring_Stem_Cell_Programmin["Offspring Stem Cell Programming"]
    MTOR_PATHWAY -->|"activates"| Vascular_Niche_Formation["Vascular Niche Formation"]
    MTOR_PATHWAY -->|"regulates"| Autophagy["Autophagy"]
    MTOR_PATHWAY -->|"causes"| epilepsy["epilepsy"]
    MTOR_PATHWAY -->|"contributes to"| neuronal_excitability["neuronal excitability"]
    MTOR_PATHWAY -->|"involved_in"| Salidroside_Induced_Cell_Death["Salidroside-Induced Cell Death"]
    AKT["AKT"] -->|"upstream_of"| MTOR_PATHWAY
    Lyso_ChR2["Lyso-ChR2"] -->|"activates"| MTOR_PATHWAY
    PI3K_AKT_pathway["PI3K-AKT pathway"] -->|"interacts"| MTOR_PATHWAY
    Hearing_Loss["Hearing Loss"] -->|"activates"| MTOR_PATHWAY
    Short_Chain_Fatty_Acids["Short-Chain Fatty Acids"] -->|"activates"| MTOR_PATHWAY
    Ferroptosis["Ferroptosis"] -->|"involved_in"| MTOR_PATHWAY
    MTOR["MTOR"] -->|"activates"| MTOR_PATHWAY
    CANCER["CANCER"] -->|"activates"| MTOR_PATHWAY

Outgoing (79)

Target	Relation	Type	Str
Offspring Stem Cell Programming	mediates	process	0.90
autophagy	inhibits	pathway	0.90
Vascular Niche Formation	activates	process	0.85
Cancer	associated_with	disease	0.85
Type 2 Diabetes	associated_with	disease	0.85
Autophagy	regulates	process	0.85
Autophagy	regulates	pathway	0.80
Salidroside-Induced Cell Death	involved_in	mechanism	0.80
epilepsy	causes	disease	0.80
neuronal excitability	contributes_to	phenotype	0.80
Autophagy	modulates	process	0.80
Amyloid-Beta	regulates	protein	0.80
Perivascular Neuroprotection	associated_with	process	0.75
ageing	regulates	process	0.70
protein function	modulates	process	0.70
AGING	regulates	phenotype	0.65
AUTOPHAGY	treats	phenotype	0.65
CELL DEATH	activates	phenotype	0.65
INFLAMMATION	regulates	phenotype	0.65
AGING	targets	phenotype	0.65
PIK3CA	regulates	gene	0.65
AGING	treats	phenotype	0.65
BREAST CANCER	inhibits	disease	0.65
REMYELINATION	implicated_in	phenotype	0.55
AMYLOID	associated_with	protein	0.50
APOE	associated_with	gene	0.50
TFEB	associated_with	gene	0.50
LDLR	associated_with	gene	0.50
APP	associated_with	gene	0.50
TAU	associated_with	protein	0.50
TNF	associated_with	gene	0.50
HK2	associated_with	gene	0.50
MITOPHAGY	associated_with	phenotype	0.50
PARKIN	associated_with	gene	0.50
TREM2	associated_with	gene	0.50
PINK1	associated_with	gene	0.50
OBESITY	associated_with	disease	0.45
EGFR	associated_with	gene	0.45
DIABETES	associated_with	disease	0.45
IDH1	associated_with	gene	0.45
QUERCETIN	associated_with	drug	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45
VEGF	associated_with	gene	0.45
VEGFA	associated_with	gene	0.45
SENESCENCE	associated_with	phenotype	0.45
SARCOPENIA	associated_with	disease	0.45
TDP-43	associated_with	protein	0.45
BAICALEIN	associated_with	drug	0.45
GLYCOLYSIS	associated_with	phenotype	0.45
TH	associated_with	gene	0.45

Incoming (136)

Source	Relation	Type	Str
APOE4	activates	gene	0.90
41545347	activates	paper	0.90
AKT	upstream_of	protein	0.90
Lyso-ChR2	activates	protein	0.88
PI3K-AKT pathway	interacts_with	pathway	0.85
Hearing Loss	activates	phenotype	0.85
Short-Chain Fatty Acids	activates	compound	0.80
Ferroptosis	involved_in	process	0.75
CANCER	targets	disease	0.65
RAPAMYCIN	treats	drug	0.65
APOE	inhibits	gene	0.55
P2RY12	inhibits	gene	0.55
NLRP3	involved_in	gene	0.55
SIRT3	involved_in	gene	0.55
PRMT1	inhibits	gene	0.55
GJA1	activates	gene	0.55
GJA1	involved_in	gene	0.55
LAMP1	activates	gene	0.55
PPARGC1A	activates	gene	0.55
RAB7A	activates	gene	0.55
ULK1	expression	gene	0.55
FKBP5	inhibits	gene	0.55
SNCA	neuroprotective	gene	0.55
TREM2	involved_in	gene	0.55
FKBP5	activates	gene	0.55
GFAP	activates	gene	0.55
LAMP1	inhibits	gene	0.55
MCOLN1	inhibits	gene	0.55
NLRP3	neuroprotective	gene	0.55
SIRT3	neuroprotective	gene	0.55
ULK1	involved_in	gene	0.55
ULK1	inhibits	gene	0.55
MMP9	inhibits	gene	0.55
STING1	interacts_with	gene	0.55
STING1	involved_in	gene	0.55
STING1	regulates	gene	0.55
C1Q	activates	gene	0.55
FOXO1	activates	gene	0.55
GLP1R	activates	gene	0.55
PLIN2	activates	gene	0.55
SIRT3	activates	gene	0.55
SREBF2	activates	gene	0.55
CHR2	activates	gene	0.55
BDNF	interacts_with	gene	0.55
SNAP25	inhibits	gene	0.55
ACSL4	modifies	gene	0.55
GPX4	modifies	gene	0.55
SLC7A11	modifies	gene	0.55
BDNF	activates	gene	0.55
TFAM	inhibits	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

What molecular mechanisms drive tissue-specific phenotypes in Mendelian neurolog

neurodegeneration | 2026-04-08 | 1 hypotheses Top: 0.280

Mechanistic role of APOE in neurodegeneration

neurodegeneration | 2026-04-01 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

The abstract identifies tissue-specific networks that may underlie Mendelian dis

closed · Rounds: 6 · Score: 0.95 · 2026-04-10

What are the mechanisms underlying mechanistic role of apoe in neurodegeneration

closed · Rounds: 5 · Score: 0.94 · 2026-04-01

Related Research

Hypotheses and analyses mentioning MTOR PATHWAY in their description or question text

No additional research found