gene

CLCN8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CLCN8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections

0Hypotheses

0Analyses

10Outgoing

0Incoming

0Experiments

0Debates

Summary

CLCN8 encodes a voltage-gated chloride channel involved in neuronal chloride homeostasis and synaptic inhibition

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🧬 Gene Info

Gene Symbol	CLCN8
Full Name	Chloride Voltage-Gated Channel 8
Chromosome	8q24.22
Protein Type	Gene
Function	is a human gene encoding a voltage-gated chloride channel protein belonging to the CLCN family of chloride channels and transporters[@jentsch2000].
Primary Expression	the central nervous system where it plays critical roles in neuronal chloride homeostasis and synaptic inhibition[@staley2006]
Molecular Weight	88 kDa
Amino Acids	803 aa
Exons	26
GeneCards	CLCN8
Human Protein Atlas	CLCN8
Proton glutamate (E166)	Critical for proton coupling and chloride transport
Gating glutamate (E207)	Involved in voltage-dependent gating
Dimerization domain	Forms the structural basis for dimer assembly
NBF1 and NBF2	Nucleotide binding folds that may regulate channel activity
Associated Diseases	Alzheimer's disease, Parkinson's disease
KG Connections	10 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CLCN8 — Chloride Voltage-Gated Channel 8

gene · 1549 words

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Pathway Diagram

graph TD
    CLCN8["CLCN8"]
    Hippo(["Hippo"])
    CLCN8 -->|"associated with"| Hippo
    IL_1_["IL-1beta"]
    CLCN8 -->|"associated with"| IL_1_
    PIK3CA["PIK3CA"]
    CLCN8 -->|"associated with"| PIK3CA
    CAPN6["CAPN6"]
    CLCN8 -->|"associated with"| CAPN6
    PI3K_AKT(["PI3K/AKT"])
    CLCN8 -->|"associated with"| PI3K_AKT
    Wnt___Catenin(["Wnt/beta-Catenin"])
    CLCN8 -->|"associated with"| Wnt___Catenin
    InsP3_Ca2_(["InsP3/Ca2+"])
    CLCN8 -->|"associated with"| InsP3_Ca2_
    antisense_oligonucleotides["antisense oligonucleotides"]
    CLCN8 -->|"associated with"| antisense_oligonucleotides
    transcription_factors["transcription factors"]
    CLCN8 -->|"associated with"| transcription_factors
    Notch(["Notch"])
    CLCN8 -->|"associated with"| Notch
    neurodegeneration["neurodegeneration"]
    CLCN8 -->|"implicated in"| neurodegeneration
    style CLCN8 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (10)

Target	Relation	Type	Str
IL-1β	associated_with	protein	0.70
Hippo	associated_with	pathway	0.70
PIK3CA	associated_with	gene	0.70
CAPN6	associated_with	gene	0.70
Wnt/β-Catenin	associated_with	pathway	0.60
transcription factors	associated_with	transcription_factor	0.60
PI3K/AKT	associated_with	pathway	0.60
InsP3/Ca2+	associated_with	pathway	0.60
antisense oligonucleotides	associated_with	drug	0.60
Notch	associated_with	pathway	0.50

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CLCN8 in their description or question text

No additional research found