gene

PRKCB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PRKCB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

37Connections

0Hypotheses

0Analyses

27Outgoing

10Incoming

0Experiments

0Debates

Summary

PRKCB is a gene implicated in neurodegeneration research. Key relationships include: expressed in, associated with, therapeutic target. Associated with Als, Alzheimer, Cancer. Connected to 38 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	PRKCB
Full Name	Protein Kinase C Beta
Chromosome	16p12.2
Function	Cell Proliferation and Differentiation: PKCβ signaling regulates cell cycle progression and phenotypic differentiation.
Subcellular Localization	patterns. In the nervous system, PKCbeta plays critical roles in synaptic plasticity, learning and memory, neuronal surv
Amino Acids	50 aa
UniProt ID	[P05771](https://www.uniprot.org/uniprot/P05771)
Ensembl ID	ENSG00000166501
OMIM	176970
GeneCards	PRKCB
Human Protein Atlas	PRKCB
Associated Diseases	Als, Alzheimer, Cancer, Dementia, Ms, Tumor
Interactions	BST2, C3
KG Connections	37 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PRKCB — Protein Kinase C Beta

gene · 1170 words

→

Pathway Diagram

graph TD
    PRKCB["PRKCB"]
    Alzheimer{"Alzheimer"}
    PRKCB -->|"associated with"| Alzheimer
    Als{"Als"}
    PRKCB -->|"activates"| Als
    Tumor{"Tumor"}
    PRKCB -->|"activates"| Tumor
    Senescence{"Senescence"}
    PRKCB -->|"expressed in"| Senescence
    Ms{"Ms"}
    PRKCB -->|"associated with"| Ms
    Dementia{"Dementia"}
    PRKCB -->|"associated with"| Dementia
    PRKCB -->|"associated with"| Als
    PRKCB -->|"therapeutic target"| Ms
    Cancer{"Cancer"}
    PRKCB -->|"therapeutic target"| Cancer
    PRKCB -->|"associated with"| Cancer
    PRKCB -->|"associated with"| Tumor
    C3["C3"]
    PRKCB -->|"activates"| C3
    BIN1["BIN1"]
    BIN1 -->|"expressed in"| PRKCB
    CDKN2A["CDKN2A"]
    CDKN2A -->|"expressed in"| PRKCB
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"expressed in"| PRKCB
    ALZHEIMER_DISEASE["ALZHEIMER DISEASE"]
    ALZHEIMER_DISEASE -->|"associated with"| PRKCB
    MAPK3["MAPK3"]
    MAPK3 -->|"therapeutic target"| PRKCB
    CDK6["CDK6"]
    CDK6 -->|"therapeutic target"| PRKCB
    EP300["EP300"]
    EP300 -->|"associated with"| PRKCB
    IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
    IMMUNE_INFILTRATION -->|"associated with"| PRKCB
    CANCER["CANCER"]
    CANCER -->|"associated with"| PRKCB
    BST2["BST2"]
    BST2 -->|"activates"| PRKCB
    style PRKCB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (27)

Target	Relation	Type	Str
Tumor	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	activates	disease	0.65
Tumor	activates	disease	0.65
Senescence	expressed_in	disease	0.65
Ms	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Als	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Cancer	associated_with	disease	0.65
C3	activates	protein	0.64
CANCER	therapeutic_target	gene	0.60
Mapk	therapeutic_target	pathway	0.60
Autophagy	expressed_in	pathway	0.60
Oxidative Stress	expressed_in	pathway	0.60
CLU	expressed_in	gene	0.60
BECN1	expressed_in	gene	0.60
CLUSTERIN	expressed_in	gene	0.60
PIK3CG	associated_with	gene	0.60
EGFR	therapeutic_target	gene	0.60
STAT3	therapeutic_target	gene	0.60
CDK4	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
AUTOPHAGY	expressed_in	gene	0.60
Calcium Signaling	expressed_in	pathway	0.60
OXIDATIVE STRESS	expressed_in	gene	0.60

Incoming (10)

Source	Relation	Type	Str
BIN1	expressed_in	gene	0.60
CDKN2A	expressed_in	gene	0.60
MAPK3	therapeutic_target	gene	0.60
CDK6	therapeutic_target	gene	0.60
EP300	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	expressed_in	gene	0.60
ALZHEIMER DISEASE	associated_with	gene	0.60
IMMUNE INFILTRATION	associated_with	gene	0.60
BST2	activates	protein	0.56

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PRKCB in their description or question text

No additional research found