gene 2,542 words KG: PIK3CG
Contents

PIK3CG Gene

🧬 Gene Info
Gene SymbolPIK3CG
Full NamePhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Chromosome7q22.3
Protein TypeReceptor
Functionis a key signaling molecule in this process
Primary Expressionhematopoietic cells including macrophages, neutrophils, T cells, and B cells [1](https://doi
PathwaysPI3K, PI3K signaling
UniProt IDP48736
NCBI Gene ID5295
Ensembl IDENSG00000110676
OMIM601298
GeneCardsPIK3CG
Human Protein AtlasPIK3CG
p84/p101 regulatory subunitsPIK3CG requires association with either p84 (PIK3R5) or p101 (PIK3R6) for membrane localization and activity
PTENThe phosphatase counteracting PI3Kγ by converting PIP3 back to PIP2
Associated DiseasesAls, Alzheimer, Dementia, Ms
InteractionsAKT, APOPTOSIS, BAX, BCL2, CANCER, CASPASE3
KG Connections65 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (14)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
Transcriptional Autophagy-Lysosome Coupling
Score: 0.88
APOE-Dependent Autophagy Restoration
Score: 0.85
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.79
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
APOE-TREM2 Interaction Modulation
Score: 0.74
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
TREM2-mediated microglial tau clearance enhancement
Score: 0.59
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.55
TREM2-Dependent Microglial Senescence Transition
Score: 0.54

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Apoptosis in Neurodegeneration
entity · KG edge: activates
Genes
index · KG edge: activates
AKT1 Gene
gene · KG edge: associated_with
BAX Gene
gene · KG edge: activates
BCL2 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

PRKCB associated_with PIK3CG
AKT inhibits PIK3CG
CASPASE3 activates PIK3CG
HSP90AA1 associated_with PIK3CG
AKT1 associated_with PIK3CG
FOXO1 associated_with PIK3CG
PIK3CG activates PI3K
PIK3CG activates BAX
PIK3CG associated_with IGF1
PIK3CG associated_with PPARA

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