gene

PIK3CD

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PIK3CD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

65Connections

0Hypotheses

0Analyses

41Outgoing

24Incoming

0Experiments

0Debates

Summary

PI3K catalytic subunit delta gene - primarily immune-expressed with roles in neuroinflammation

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🧬 Gene Info

Gene Symbol	PIK3CD
Aliases	PI3K catalytic subunit delta gene
Chromosome	1p36.22
Protein Type	Gene
Function	encodes a protein of 1,048 amino acids with a molecular weight of approximately 110 kDa.
Primary Expression	immune cells including T cells, B cells, natural killer cells, mast cells, and macrophages
Molecular Weight	110 kDa
Amino Acids	048 aa
Pathways	PI3K
GeneCards	PIK3CD
Human Protein Atlas	PIK3CD
p85-binding domain	Interacts with p85 regulatory subunits (PIK3R1, PIK3R2) that control enzyme activity and localization
C2 domain	Binds to cellular membranes through interactions with phospholipids
Helical domain	Involved in protein-protein interactions
Kinase domain	The catalytic center that phosphorylates PIP2 to generate PIP3
Associated Diseases	Alzheimer's disease, Parkinson's disease
Known Drugs/Compounds	dasatinib
Interactions	AKT, AKT1, AND, CANCER, GENES, INFLAMMATION
KG Connections	65 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PIK3CD Gene

gene · 1070 words

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Pathway Diagram

graph TD
    PIK3CD["PIK3CD"]
    Inflammation{"Inflammation"}
    PIK3CD -->|"expressed in"| Inflammation
    Glioblastoma{"Glioblastoma"}
    PIK3CD -->|"expressed in"| Glioblastoma
    Als{"Als"}
    PIK3CD -->|"expressed in"| Als
    Cancer{"Cancer"}
    PIK3CD -->|"expressed in"| Cancer
    Carcinoma{"Carcinoma"}
    PIK3CD -->|"expressed in"| Carcinoma
    PIK3CD -->|"therapeutic target"| Carcinoma
    PIK3CD -->|"therapeutic target"| Cancer
    Tumor{"Tumor"}
    PIK3CD -->|"therapeutic target"| Tumor
    PI3K["PI3K"]
    PIK3CD -->|"expressed in"| PI3K
    INFLAMMATION["INFLAMMATION"]
    PIK3CD -->|"expressed in"| INFLAMMATION
    CANCER["CANCER"]
    PIK3CD -->|"expressed in"| CANCER
    Pi3K(["Pi3K"])
    PIK3CD -->|"expressed in"| Pi3K
    PIK3CA["PIK3CA"]
    PIK3CA -->|"therapeutic target"| PIK3CD
    MTOR["MTOR"]
    MTOR -->|"therapeutic target"| PIK3CD
    style PIK3CD fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (41)

Target	Relation	Type	Str
Senescent Cells	involved_in	cell_type	0.85
apoptosis resistance	mediates	process	0.85
Carcinoma	therapeutic_target	disease	0.65
Aging	activates	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
Atherosclerosis	activates	disease	0.65
Inflammation	activates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Glioblastoma	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
Inflammation	expressed_in	disease	0.65
Atherosclerosis	therapeutic_target	disease	0.65
Fibrosis	activates	disease	0.65
EGFR	therapeutic_target	gene	0.60
AKT1	activates	gene	0.60
Akt	activates	pathway	0.60
AND	activates	gene	0.60
AKT	activates	gene	0.60
Pi3K	activates	pathway	0.60
MIRNAS	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
MICRORNAS	therapeutic_target	gene	0.60
Akt	therapeutic_target	pathway	0.60
Mtor	therapeutic_target	pathway	0.60
Pi3K	therapeutic_target	pathway	0.60
KRAS	therapeutic_target	gene	0.60
PI3K	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
PIK3R3	therapeutic_target	gene	0.60
AKT3	therapeutic_target	gene	0.60
PIK3CB	therapeutic_target	gene	0.60
PIK3R1	therapeutic_target	gene	0.60
Pi3K	expressed_in	pathway	0.60
MTOR	therapeutic_target	gene	0.60
INFLAMMATION	expressed_in	gene	0.60
CANCER	expressed_in	gene	0.60
PI3K	expressed_in	gene	0.60

Incoming (24)

Source	Relation	Type	Str
dasatinib	targets	drug	0.75
PIK3R3	therapeutic_target	gene	0.60
PIK3CB	therapeutic_target	gene	0.60
PI3K	therapeutic_target	gene	0.60
AKT3	therapeutic_target	gene	0.60
PIK3R1	therapeutic_target	gene	0.60
MICRORNAS	therapeutic_target	gene	0.60
AND	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
MIRNAS	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
INFLAMMATION	activates	gene	0.60
INS	activates	gene	0.60
GENES	activates	gene	0.60
CANCER	activates	gene	0.60
PIK3CA	therapeutic_target	gene	0.60
CD8	therapeutic_target	gene	0.60
PI3K	activates	gene	0.60
SRC	therapeutic_target	gene	0.60
JAK2	therapeutic_target	gene	0.60
PIK3CG	therapeutic_target	gene	0.60
HRAS	therapeutic_target	gene	0.60
RAGE	activates	gene	0.60
MTOR	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PIK3CD in their description or question text

No additional research found