gene

INPP4A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about INPP4A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections

0Hypotheses

0Analyses

10Outgoing

5Incoming

0Experiments

0Debates

Summary

INPP4A (inositol polyphosphate-4-phosphatase type I) is a novel Parkinson's disease therapeutic target from recent multi-omics studies. It regulates the phosphatidylinositol cycle in the endolysosomal pathway.

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🧬 Gene Info

Gene Symbol	INPP4A
Full Name	Inositol Polyphosphate-4-Phosphatase Type I
Chromosome	9q34.3
Protein Type	Phosphatase
Function	encodes a lipid phosphatase that plays a critical role in phosphatidylinositol (PI) signaling pathways.
Primary Expression	dopaminergic neurons of the substantia nigra pars compacta, the precise neuronal population that degenerates in Parkinson's disease
Subcellular Localization	INPP4A exhibits specific subcellular distribution that informs its function:
Molecular Weight	113 kDa
Amino Acids	1028 aa
Exons	22
UniProt ID	[Q9Y2K2](https://www.uniprot.org/uniprot/Q9Y2K2)
Ensembl ID	ENSG00000116678
GeneCards	INPP4A
Human Protein Atlas	INPP4A
Early endosomes	Colocalizes with early endosome markers (EEA1, Rab5)
Associated Diseases	Als
KG Connections	15 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

INPP4A Gene - Inositol Polyphosphate-4-Phosphatase Type I

gene · 2444 words

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Pathway Diagram

graph TD
    INPP4A["INPP4A"]
    INPP4A -->|"causes"| Als["Als"]
    INPP4A -->|"causes"| ALS["ALS"]
    INPP4A -->|"causes"| App["App"]
    INPP4A -->|"implicated in"| neurodegeneration["neurodegeneration"]
    INPP4A ---|"associated"| P2RX7["P2RX7"]
    INPP4A ---|"associated"| SCN10A["SCN10A"]
    INPP4A ---|"associated"| XPR1["XPR1"]
    INPP4A ---|"associated"| CAMSAP1["CAMSAP1"]
    INPP4A ---|"associated"| Genes["Genes"]
    AND["AND"] -->|"causes"| INPP4A
    P2RX7 ---|"associated"| INPP4A
    XPR1 ---|"associated"| INPP4A
    SCN10A ---|"associated"| INPP4A
    GENES["GENES"] ---|"associated"| INPP4A

Outgoing (10)

Target	Relation	Type	Str
Als	causes	disease	0.65
ALS	causes	disease	0.65
XPR1	associated_with	gene	0.60
App	causes	protein	0.60
P2RX7	associated_with	gene	0.60
SCN10A	associated_with	gene	0.60
ALS	associated_with	disease	0.60
P2RX7	co_expressed_with	gene	0.50
SCN10A	co_expressed_with	gene	0.50
CAMSAP1	associated_with	protein	0.50

Incoming (5)

Source	Relation	Type	Str
P2RX7	associated_with	gene	0.60
SCN10A	associated_with	gene	0.60
GENES	associated_with	gene	0.60
XPR1	associated_with	gene	0.60
CAMSAP1	co_expressed_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning INPP4A in their description or question text

No additional research found