protein

NT5E

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NT5E: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

37Connections

0Hypotheses

0Analyses

21Outgoing

16Incoming

0Experiments

0Debates

Summary

Page for NT5E Protein

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🔬 Protein Info

Gene Symbol	NT5E
Full Name	Ecto-5'-Nucleotidase
Chromosome	6q14.3
Protein Type	Enzyme
Function	CD73 is a glycosylphosphatidylinositol (GPI)-anchored cell surface enzyme that hydrolyzes extracellular nucleotides to adenosine
Primary Expression	the central nervous system (CNS), where it modulates synaptic transmission, neuroinflammation, and blood-brain barrier (BBB) function
Subcellular Localization	** \| Cell surface (GPI-anchored), cytoplasm \|
Molecular Weight	70 kDa
Amino Acids	320 aa
Pathways	Lipid Metabolism
UniProt ID	P21589
NCBI Gene ID	4904
Ensembl ID	ENSG00000135318
OMIM	602872
GeneCards	NT5E
Human Protein Atlas	NT5E
Associated Diseases	ALS, Alzheimer, dementia
KG Connections	37 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NT5E — AlphaFold P21589 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NT5E["NT5E"]
    Alzheimer{"Alzheimer"}
    NT5E -->|"regulates"| Alzheimer
    Als{"Als"}
    NT5E -->|"regulates"| Als
    Dementia{"Dementia"}
    NT5E -->|"regulates"| Dementia
    ALS{"ALS"}
    NT5E -->|"regulates"| ALS
    Inflammation{"Inflammation"}
    NT5E -->|"regulates"| Inflammation
    P2RX7(["P2RX7"])
    P2RX7 -->|"expressed_in"| NT5E
    DEMENTIA(["DEMENTIA"])
    DEMENTIA -->|"regulates"| NT5E
    GENES(["GENES"])
    GENES -->|"expressed_in"| NT5E
    INFLAMMATION(["INFLAMMATION"])
    INFLAMMATION -->|"regulates"| NT5E
    style NT5E fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7

Outgoing (21)

Target	Relation	Type	Str
Als	regulates	disease	0.65
Dementia	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
ALS	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Dementia	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Lipid Metabolism	expressed_in	pathway	0.60
Cytokine	expressed_in	protein	0.60
App	regulates	protein	0.60
P2RX7	associated_with	gene	0.60
NLRP3	expressed_in	gene	0.60
HSP90AA1	expressed_in	gene	0.60
ALZHEIMER	regulates	gene	0.60
DEMENTIA	regulates	gene	0.60
ALS	associated_with	disease	0.60
Lipid Metabolism	regulates	pathway	0.60
dementia	associated_with	disease	0.60
Alzheimer	associated_with	disease	0.60
P2RX7	co_expressed_with	gene	0.50

Incoming (16)

Source	Relation	Type	Str
ALZHEIMER	expressed_in	gene	0.60
DEMENTIA	expressed_in	gene	0.60
P2RX7	expressed_in	gene	0.60
NLRP3	expressed_in	gene	0.60
HSP90AA1	expressed_in	gene	0.60
DEMENTIA	regulates	gene	0.60
GENES	expressed_in	gene	0.60
INFLAMMATION	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
HUB GENES	expressed_in	gene	0.60
P2RX7	associated_with	gene	0.50
HSP90AA1	associated_with	gene	0.50
NLRP3	associated_with	protein	0.50
HSP90AA1	co_expressed_with	gene	0.50
NLRP3	co_expressed_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NT5E in their description or question text

No additional research found