| Gene Symbol | P2RX7 |
| Full Name | Purinergic Receptor P2X Ligand-Gated Ion Channel 7 |
| Chromosome | 12 |
| Protein Type | Ion Channel |
| Target Class | Ion Channel |
| Function | Selective P2X7 receptor antagonists blocking ATP-gated ion channel |
| Mechanism of Action | Selective P2X7 receptor antagonists blocking ATP-gated ion channel |
| Druggability | High (0.80) |
| Clinical Stage | Phase II |
| Molecular Weight | 68.6 kDa |
| Amino Acids | 595 aa |
| Pathways | Glucose Metabolism, Lipid Metabolism, Phagocytosis, tau accumulation, tau propagation |
| UniProt ID | Q99572 |
| NCBI Gene ID | 10278 |
| Ensembl ID | ENSG00000088038 |
| OMIM | 601636 |
| GeneCards | P2RX7 |
| Human Protein Atlas | P2RX7 |
| Associated Diseases | Als, Alzheimer, Alzheimer's disease, Autoimmune |
| Known Drugs/Compounds | therapeutic_target |
| Interactions | ACHE, AD, adora2b, ADORA2B, Alpha-Synuclein, ALPHA-SYNUCLEIN |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | P2RX7-Mediated Exosome Secretion Blockade |
| KG Connections | 672 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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