gene

SCN10A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SCN10A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections

0Hypotheses

0Analyses

9Outgoing

6Incoming

0Experiments

0Debates

Summary

Sodium Voltage-Gated Channel Alpha Subunit 10 (Nav1.8) - pain-sensing sodium channel implicated in small fiber neuropathy, cardiac arrhythmias, and neurodegeneration

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🧬 Gene Info

Gene Symbol	SCN10A
Full Name	Sodium Voltage-Gated Channel Alpha Subunit 10
Aliases	Nav1.8
Chromosome	3p21
Protein Type	Channel
Function	is a member of the Nav1 family of voltage-gated sodium channels (Na<sub>v</sub>1.
Primary Expression	Peripheral sensory neurons, cardiac conduction system, sympathetic neurons
Molecular Weight	220 kDa
Amino Acids	2016 aa
Exons	26 coding exons
UniProt ID	Q9Y5Y9
NCBI Gene ID	6336
Ensembl ID	ENSG00000185313
OMIM	613217
GeneCards	SCN10A
Human Protein Atlas	SCN10A
Associated Diseases	Als
KG Connections	15 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SCN10A — AlphaFold Q9Y5Y9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SCN10A Gene

gene · 1894 words

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SCN10A Protein (Nav1.8)

protein · 664 words

→

Pathway Diagram

graph TD
    SCN10A["SCN10A"]
    SCN10A -->|"causes"| Als["Als"]
    SCN10A -->|"causes"| ALS["ALS"]
    SCN10A -->|"causes"| AND["AND"]
    SCN10A -->|"causes"| App["App"]
    SCN10A -->|"implicated in"| neurodegeneration["neurodegeneration"]
    SCN10A ---|"associated"| INPP4A["INPP4A"]
    SCN10A ---|"associated"| XPR1["XPR1"]
    SCN10A ---|"associated"| P2RX7["P2RX7"]
    SCN10A ---|"associated"| CAMSAP1["CAMSAP1"]
    SCN10A ---|"associated"| Genes["Genes"]
    P2RX7 ---|"associated"| SCN10A
    XPR1 ---|"associated"| SCN10A
    GENES["GENES"] ---|"associated"| SCN10A
    INPP4A ---|"associated"| SCN10A

Outgoing (9)

Target	Relation	Type	Str
Als	causes	disease	0.65
ALS	causes	disease	0.65
INPP4A	associated_with	gene	0.60
P2RX7	associated_with	gene	0.60
XPR1	associated_with	gene	0.60
AND	causes	gene	0.60
App	causes	protein	0.60
ALS	associated_with	disease	0.60
CAMSAP1	associated_with	protein	0.50

Incoming (6)

Source	Relation	Type	Str
INPP4A	associated_with	gene	0.60
GENES	associated_with	gene	0.60
P2RX7	associated_with	gene	0.60
XPR1	associated_with	gene	0.60
INPP4A	co_expressed_with	gene	0.50
P2RX7	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SCN10A in their description or question text

No additional research found