concept

EXTRACELLULAR VESICLES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EXTRACELLULAR VESICLES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

162Connections

5Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	EXTRACELLULAR VESICLES
Key Genes/Proteins	AGO2, ALZHEIMER, AMYLOID-BETA, amyotrophic lateral sclerosis, CAV1, CAVEOLIN-1
Related Diseases	cancer, Cardiovascular, disease
Related Pathways	COMPLEMENT

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Extracellular Vesicles in Neurodegeneration

mechanisms · 3331 words

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Pathway Diagram

graph TD
    EXTRACELLULAR_VESICLES["EXTRACELLULAR VESICLES"]
    EXTRACELLULAR_VESICLES -->|"modulates"| Liver["Liver"]
    EXTRACELLULAR_VESICLES -->|"modulates"| Tumor_Microenvironment["Tumor Microenvironment"]
    EXTRACELLULAR_VESICLES -->|"mediates"| Angiogenesis["Angiogenesis"]
    EXTRACELLULAR_VESICLES -->|"mediates"| Intercellular_Communication["Intercellular Communication"]
    EXTRACELLULAR_VESICLES -->|"mediates"| Metabolic_Dysfunction["Metabolic Dysfunction"]
    EXTRACELLULAR_VESICLES -->|"promotes"| dopaminergic_cell_death["dopaminergic cell death"]
    EXTRACELLULAR_VESICLES -.biomarker for.-> Sarcopenia["Sarcopenia"]
    EXTRACELLULAR_VESICLES -->|"mediates"| Mitochondrial_Targeting["Mitochondrial Targeting"]
    candesartan["candesartan"] -->|"inhibits"| EXTRACELLULAR_VESICLES
    GJA1["GJA1"] -->|"regulates"| EXTRACELLULAR_VESICLES
    EXOSOMES["EXOSOMES"] -->|"interacts"| EXTRACELLULAR_VESICLES
    BLOOD_BRAIN_BARRIER["BLOOD-BRAIN BARRIER"] -->|"interacts"| EXTRACELLULAR_VESICLES
    AKT["AKT"] -->|"regulates"| EXTRACELLULAR_VESICLES
    EXTRACELLULAR_MATRIX["EXTRACELLULAR MATRIX"] -.biomarker for.-> EXTRACELLULAR_VESICLES
    CANCER["CANCER"] -->|"activates"| EXTRACELLULAR_VESICLES

Outgoing (50)

Target	Relation	Type	Str
Metastatic Tumor Microenvironment	associated_with	phenotype	0.95
Fatty Liver	associated_with	disease	0.95
Mitochondria	transports	cell_type	0.95
Fatty Liver	expressed_in	disease	0.95
TARDBP	transports	protein	0.95
MAPT	transports	protein	0.95
Microglia	interacts_with	cell_type	0.92
tumor microenvironment	promotes	phenotype	0.92
Liver	modulates	cell_type	0.90
Intercellular Communication	mediates	process	0.90
metastasis	promotes	process	0.90
miR-206-3p	associated_with	drug	0.90
Tumor Microenvironment	modulates	phenotype	0.90
Liver	targets	cell_type	0.90
Angiogenesis	mediates	process	0.90
Metabolic Dysfunction	mediates	phenotype	0.88
metabolic maturation	mediates	phenotype	0.88
angiogenesis	promotes	process	0.87
dopaminergic cell death	promotes	process	0.87
Alzheimer Disease	therapeutic_target	disease	0.85
Sarcopenia	biomarker_for	disease	0.85
Tumor Metastasis	mediates	process	0.85
Mitochondrial Targeting	mediates	mechanism	0.85
Mitochondrial Protection	associated_with	process	0.85
Disease Biomarker	associated_with	biomarker	0.85
Functional Recovery	associated_with	phenotype	0.85
Systemic metabolism	regulates	pathway	0.80
Tissue Repair	mediates	process	0.80
immune cell infiltration	mediates	process	0.80
Immune System	participates_in	process	0.80
Antigen Presentation	participates_in	process	0.80
Physiological Functions	associated_with	process	0.80
Immune Modulation	mediates	process	0.80
cryptic peptides	expressed_in	compound	0.80
amyloid-beta	mediates	compound	0.80
tau	mediates	protein	0.80
Organ Biodistribution	associated_with	phenotype	0.80
LGALS9	mediates	protein	0.80
systemic inflammation	promotes	process	0.78
IL12B	upregulates	gene	0.75
Neurodegeneration	contributes_to	disease	0.75
Drug Delivery	associated_with	process	0.70
phosphorylated tau	mediates	protein	0.70
cell-to-cell communication	regulates	process	0.70
quality control	promotes	process	0.70
THBS1	associated_with	protein	0.70
ANGPT1	associated_with	protein	0.70
COL1A1	associated_with	protein	0.70
Neuroinflammation	modulates	process	0.60
CHRONIC INFLAMMATION	activates	concept	0.50

Incoming (112)

Source	Relation	Type	Str
fatty liver	promotes	phenotype	0.95
P2RX7	regulates	gene	0.95
MIR130A	expressed_in	gene	0.92
TGFB1	expressed_in	protein	0.90
32428221	have been implicated in	paper	0.90
38898538	protect during systemic circulation	paper	0.90
40395520	occurs via	paper	0.90
Brown Adipose Tissue	associated_with	cell_type	0.90
ITGAV	targets	gene	0.90
ITGB8	targets	gene	0.90
candesartan	inhibits	drug	0.88
hepatic steatosis	associated_with	disease	0.85
cryptic peptides	expressed_in	compound	0.85
Cancer	associated_with	disease	0.85
Sarcopenia	associated_with	disease	0.85
GJA1	involved_in	gene	0.80
LRRK2	promotes	protein	0.70
ASTROCYTE	expresses	gene	0.70
GJA1	regulates	gene	0.70
motor skill learning	modulates	process	0.70
38898538	participate in	paper	0.60
38898538	mirror of	paper	0.60
cancer	activates	disease	0.50
TUMOR	activates	disease	0.50
Tumor Microenvironment	activates	process	0.50
Fatty Liver	activates	disease	0.50
Autophagy	regulates	process	0.50
GJA1	regulates	gene	0.50
Tdp-43	associated_with	pathway	0.50
Proteins	interacts_with	protein	0.50
AMYLOID-BETA	activates	protein	0.50
ALZHEIMER	activates	gene	0.50
Neuron	activates	cell_type	0.50
EXOSOMES	activates	concept	0.50
AGO2	inhibits	protein	0.50
CAV1	inhibits	gene	0.50
TUMOR	inhibits	disease	0.50
MITOCHONDRIA	regulates	cell_type	0.50
P2RX7	regulates	gene	0.50
Tauopathy	regulates	disease	0.50
microglia	activates	cell_type	0.50
P2RX7	activates	gene	0.50
RAB27A	activates	protein	0.50
STROKE	activates	gene	0.50
Cellular Senescence	associated_with	cell_type	0.50
STEM CELLS	associated_with	concept	0.50
MITOCHONDRIA	activates	cell_type	0.50
PI3K/AKT PATHWAY	interacts_with	concept	0.50
PERICYTE	associated_with	concept	0.50
PERICYTES	associated_with	concept	0.50

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Hypothesis 3: HepaCAM-Containing Extracellular Vesicles	0.762	neurodegeneration	View
GFAP-Bearing Circulating Extracellular Vesicles Originating	0.665	-	What blood-brain barrier permeability ch
Blocking Tau Packaging into Small Extracellular Vesicles via	0.610	neuroscience	Trans-synaptic tau spreading and propaga
Ganglioside-rich extracellular vesicles preserve alpha-synuc	0.582	neurodegeneration	Which specific CSF molecular components
Tumor-derived extracellular vesicles as TREM2 ligands	0.490	neurodegeneration	Does the cancer-cystatin-C-TREM2 pathway

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (6)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Recent Developments in Diabetic Retinal Neurodegeneration: A Literature Review. [PMID:34151902]	Unknown	J Diabetes Res	2020
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Multiple Sclerosis Pathology. [PMID:29358320]	Lassmann H	Cold Spring Harbor perspective	2018
Infectious agents and neurodegeneration. [PMID:22899188]	De Chiara G, Marcocci ME, Sgarbanti R, C	Molecular neurobiology	2012
TNF-alpha signaling in glaucomatous neurodegeneration. [PMID:18929124]	Unknown	Prog Brain Res	2008

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning EXTRACELLULAR VESICLES in their description or question text

No additional research found