Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GEM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GEM is a gene implicated in neurodegeneration research. Key relationships include: inhibits, activates, regulates. Associated with Cancer, Carcinoma, Ms. Connected to 27 entities in the SciDEX knowledge graph.
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| Gene Symbol | GTP-Binding Protein GEM |
| Chromosome | 8q22.1 |
| Protein Type | Small GTPase (Rad/Gem/Kir family) |
| Function | is a member of the Rad/Gem/Kir family of small GTP-binding proteins. |
| Primary Expression | Brain (cortex, hippocampus, cerebellum), heart, skeletal muscle |
| Pathways | Immune Response, Pi3K, Pi3K/Akt |
| UniProt ID | P55042 |
| NCBI Gene ID | 2664 |
| Ensembl ID | ENSG00000164946 |
| OMIM | 605394 |
| Associated Diseases | Cancer, Carcinoma |
| Interactions | AKT, AND, APOPTOSIS, CANCER, CAV1, DDIT3 |
| KG Connections | 57 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
GEM["GEM"]
Ms{"Ms"}
GEM -->|"activates"| Ms
Carcinoma{"Carcinoma"}
GEM -->|"inhibits"| Carcinoma
Cancer{"Cancer"}
GEM -->|"inhibits"| Cancer
Tumor{"Tumor"}
GEM -->|"inhibits"| Tumor
STING["STING"]
GEM -->|"interacts with"| STING
MAVS["MAVS"]
GEM -->|"interacts with"| MAVS
Toll_Like_Receptor(["Toll-Like Receptor"])
GEM -->|"interacts with"| Toll_Like_Receptor
Immune_Response(["Immune Response"])
GEM -->|"activates"| Immune_Response
AKT["AKT"]
GEM -->|"inhibits"| AKT
CANCER["CANCER"]
GEM -->|"inhibits"| CANCER
DDIT3["DDIT3"]
GEM -->|"inhibits"| DDIT3
Akt(["Akt"])
GEM -->|"inhibits"| Akt
MTOR["MTOR"]
MTOR -->|"inhibits"| GEM
style GEM fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Tumor | inhibits | disease | 0.75 |
| Cancer | inhibits | disease | 0.65 |
| Pancreatic Cancer | regulates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| Carcinoma | inhibits | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| Leukemia | activates | disease | 0.65 |
| Carcinoma | associated_with | disease | 0.65 |
| Leukemia | inhibits | disease | 0.65 |
| Ras | activates | protein | 0.60 |
| AKT | inhibits | gene | 0.60 |
| DDIT3 | inhibits | gene | 0.60 |
| Apoptosis | inhibits | pathway | 0.60 |
| Chemoresistance | inhibits | pathway | 0.60 |
| STING | interacts_with | gene | 0.60 |
| MAVS | interacts_with | gene | 0.60 |
| OLIG2 | inhibits | gene | 0.60 |
| SHH | inhibits | gene | 0.60 |
| SHH | associated_with | gene | 0.60 |
| Toll-Like Receptor | interacts_with | pathway | 0.60 |
| CANCER | inhibits | gene | 0.60 |
| Immune Response | activates | pathway | 0.60 |
| Akt | inhibits | pathway | 0.60 |
| Mtor | inhibits | pathway | 0.60 |
| CANCER | regulates | gene | 0.60 |
| Pi3K/Akt | activates | pathway | 0.60 |
| Cell Cycle | inhibits | pathway | 0.60 |
| STAT3 | activates | gene | 0.60 |
| UBIQUITIN | activates | gene | 0.60 |
| cancer | interacts_with | disease | 0.60 |
| Phagocytosis | inhibits | pathway | 0.60 |
| RNA | activates | gene | 0.60 |
| Fibroblast | associated_with | cell_type | 0.60 |
| AND | activates | gene | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| complement cascade | participates_in | pathway | 0.60 |
| P53 | activates | gene | 0.60 |
| PHAGOCYTOSIS | inhibits | gene | 0.60 |
| Wnt | inhibits | pathway | 0.60 |
| Pi3K | activates | pathway | 0.60 |
| WNT | inhibits | gene | 0.60 |
| AKT | activates | gene | 0.60 |
| CAV1 | activates | gene | 0.60 |
| LIF | activates | gene | 0.60 |
| Fibroblast | expressed_in | cell_type | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Direct ISR target engagement likely requires trazodone doses | 0.590 | neurodegeneration | - |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning GEM in their description or question text
No additional research found