Contents

OCLN — Occludin

🧬 Gene Info

Gene Symbol	OCLN
Full Name	Occludin
Chromosome	5q13.2
Protein Type	Structural Protein
Target Class	Structural Protein
Function	Drugs targeting OCLN would stabilize or enhance tight junction protein interactions, reinforcing the structural integrity of the blood-brain barrier and reducing pathological barrier permeability. ...
Mechanism of Action	Drugs targeting OCLN would stabilize or enhance tight junction protein interactions, reinforcing the structural integrity of the blood-brain barrier and reducing pathological barrier permeability. Therapeutic approaches would involve either direct protein stabilization or indirect modulation of occludin phosphorylation and trafficking to maintain barrier function.
Primary Expression	Brain endothelial cells, Epithelial tight junctions
Druggability	Low (0.32)
Clinical Stage	Approved
Molecular Weight	65 kDa
Amino Acids	522 aa
Pathways	Autophagy, Blood-Brain Barrier, Circadian Rhythm, Immune Response, Innate Immunity
UniProt ID	Q16625
NCBI Gene ID	4950
Ensembl ID	ENSG00000130940
OMIM	602876
GeneCards	OCLN
Human Protein Atlas	OCLN
Associated Diseases	Aging, Als, Alzheimer, anxiety
Known Drugs/Compounds	BENVITIMOD, BYF
Interactions	ABCB1, ABCG2, ACHE, ACTB, Actin, Adiponectin
SciDEX Target	View Target Profile (10 clinical trials)
KG Connections	844 knowledge graph edges
Databases	GeneCards HPA STRING

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