| Gene Symbol | ent-gene-79cc1a56 |
| Cohorts | 635 participants from two independent cohorts (CANDI in China and DDI in Norway) |
| Measurements | CSF levels of NPTX1 and NPTXR alongside established markers (p-tau181, Aβ42/Aβ40 ratio, cortical thickness) |
| Follow-up | 64 MCI participants followed for 2.5 years |
| NPTX1 (Neuronal Pentraxin-1) | A soluble protein expressed primarily in neurons that participates in synaptic plasticity and complement-mediated phagocytosis[@kaj2026] |
| NPTXR (Neuronal Pentraxin Receptor) | A membrane-bound receptor that clusters at synapses and regulates synaptic organization |
| NPTX2 (Neuronal Pentraxin-2) | Another family member involved in synaptic development |
| AUC for MCI-to-dementia progression | 0.80 (80% accuracy) |
| Sensitivity | 78% for identifying rapid progressors |
| Specificity | 82% for identifying stable MCI |
| Positive predictive value | 75% in the combined cohort |
| Amyloid-positive MCI | Best predictive accuracy (AUC = 0.85) |
| APOE ε4 carriers | Slightly lower specificity but maintained sensitivity |
| Early-stage AD | Higher baseline levels predicted faster progression |
| Vascular cognitive impairment | Lower discriminative ability (AUC = 0.65)[@zhou2018] |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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