gene 566 words KG: NPTX1
Contents

NPTX1 — Neuronal Pentraxin 1

🧬 Gene Info
Gene SymbolNPTX1
Full NameNeuronal Pentraxin 1
FunctionNeuronal Pentraxin 1 (NPTX1) is a member of the pentraxin family of proteins, which are characterized by their ability to bind to phosphatidylserine and apoptotic cells.
Molecular Weight47 kDa
Amino Acids430 aa
Pathwaysoxidative stress response
Ensembl IDENSG00000143157
GeneCardsNPTX1
Human Protein AtlasNPTX1
Associated DiseasesInflammation, Neuroinflammation
InteractionsAMYLOID, CHI3L1, CHIT1, CST3, CTSB, CTSD
KG Connections111 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (9)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68

Related Analyses (3)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Metabolic reprogramming in neurodegenerative disease
neurodegeneration · completed

Related Experiments (3)

Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40

See Also (12)

Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: biomarker_for
GFAP (Redirect)
redirect · KG edge: biomarker_for
BDNF Gene
gene · KG edge: biomarker_for
CHI3L1 Gene
gene · KG edge: associated_with
CHIT1 Gene (Chitinase 1)
gene · KG edge: associated_with

Knowledge Graph (12 edges)

IL9 biomarker_for NPTX1
VEGFA associated_with NPTX1
IL4 biomarker_for NPTX1
FGF2 biomarker_for NPTX1
GFAP biomarker_for NPTX1
NPTX1 associated_with CHIT1
NPTX1 biomarker_for MDH1
NPTX1 associated_with PDGFRB
NPTX1 biomarker_for SQSTM1
NPTX1 biomarker_for BDNF

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