protein 2,155 words KG: NPTX1
Contents

NPTX1 Protein

🔬 Protein Info
Gene SymbolNPTX1
AliasesNeuronal Pentraxin 1
FunctionNeuronal Pentraxin 1 (NPTX1) is a member of the pentraxin family of proteins, which are characterized by their ability to bind to phosphatidylserine and apoptotic cells.
Subcellular Localization</strong></td><td>Extracellular, synaptic vesicles, secreted</td></tr>
Molecular Weight47 kDa
Amino Acids430 aa
Pathwaysoxidative stress response
Ensembl IDENSG00000143157
GeneCardsNPTX1
Human Protein AtlasNPTX1
PentamersBasic structural unit
Higher-order aggregatesFormed under certain conditions
Heteromeric complexesCan interact with NPTX2
Associated DiseasesInflammation, Neuroinflammation
InteractionsAMYLOID, CHI3L1, CHIT1, CST3, CTSB, CTSD
KG Connections110 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (14)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
SASP-Mediated Complement Cascade Amplification
Score: 0.70
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (6)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Key Papers (1)

Randomized control trial of evaluation of Clemastine effects on visual
Clinical neurology and neurosu 2020

See Also (11)

Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: biomarker_for
GFAP (Redirect)
redirect · KG edge: biomarker_for
BDNF Gene
gene · KG edge: biomarker_for
CHI3L1 Gene
gene · KG edge: associated_with
CHIT1 Gene (Chitinase 1)
gene · KG edge: associated_with

Knowledge Graph (12 edges)

IL9 biomarker_for NPTX1
VEGFA associated_with NPTX1
IL4 biomarker_for NPTX1
FGF2 biomarker_for NPTX1
GFAP biomarker_for NPTX1
NPTX1 associated_with CHIT1
NPTX1 biomarker_for MDH1
NPTX1 associated_with PDGFRB
NPTX1 biomarker_for SQSTM1
NPTX1 biomarker_for BDNF

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