concept

AGEING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AGEING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

54Connections

0Hypotheses

0Analyses

28Outgoing

26Incoming

0Experiments

0Debates

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💡 Concept Info

Name	AGEING

Pathway Diagram

graph TD
    AGEING["AGEING"]
    AGEING -->|"risk_factor_for"| Alzheimer_Disease["Alzheimer Disease"]
    AGEING -->|"risk_factor_for"| Parkinson_Disease["Parkinson Disease"]
    AGEING -->|"risk_factor_for"| Neurodegenerative_Diseases["Neurodegenerative Diseases"]
    AGEING -->|"risk_factor_for"| Alzheimer_s_Disease["Alzheimer's Disease"]
    AGEING -->|"risk_factor_for"| neurodegenerative_diseases["neurodegenerative diseases"]
    AGEING -->|"downregulates"| Neural_Resilience["Neural Resilience"]
    AGEING -->|"causes"| Cognitive_Decline["Cognitive Decline"]
    AGEING -->|"promotes"| cognitive_decline["cognitive decline"]
    AMPK["AMPK"] -->|"modulates"| AGEING
    Sirtuins["Sirtuins"] -->|"modulates"| AGEING
    lithocholic_acid["lithocholic acid"] -.prevents.-> AGEING
    LCA["LCA"] -->|"suppresses"| AGEING
    mTOR["mTOR"] -->|"regulates"| AGEING

Outgoing (28)

Target	Relation	Type	Str
Alzheimer's Disease	risk_factor_for	disease	0.95
alzheimer_disease	increases_risk	disease	0.95
Parkinson Disease	risk_factor_for	disease	0.95
neurodegenerative diseases	risk_factor_for	disease	0.95
Alzheimer Disease	risk_factor_for	disease	0.95
Neurodegenerative Diseases	risk_factor_for	disease	0.95
Osteoarthritis	risk_factor_for	disease	0.95
Parkinson'S Disease	risk_factor_for	disease	0.95
Alzheimer'S Disease	risk_factor_for	disease	0.95
mitochondrial_dysfunction	associated_with	mechanism	0.95
cognitive decline	promotes	phenotype	0.90
Cardiovascular Disease	risk_factor_for	disease	0.90
Neural Susceptibility To Injury	associated_with	phenotype	0.90
Neural Resilience	downregulates	phenotype	0.90
Cognitive Decline	causes	phenotype	0.90
Sarcopenia	associated_with	disease	0.90
Cardiovascular Disease	contributes_to	disease	0.85
Neurodegeneration	risk_factor_for	process	0.85
vascular pathologies	promotes	phenotype	0.85
Brain Function	downregulates	phenotype	0.85
neuroinflammation	associated_with	mechanism	0.80
Vascular Pathologies	causes	disease	0.80
Molecular Mechanisms	associated_with	mechanism	0.80
Disease	increases_risk	disease	0.80
Alzheimer's disease	causes	disease	0.70
Parkinson's disease	activates	disease	0.70
Alzheimer's disease	activates	disease	0.70
Parkinson's disease	causes	disease	0.70

Incoming (26)

Source	Relation	Type	Str
AMPK	modulates	protein	0.95
AMPK	suppresses	protein	0.95
Low-Grade Inflammation	associated_with	process	0.95
Sirtuins	modulates	protein	0.90
MTORC1	associated_with	protein	0.90
34415665	is a risk factor for	paper	0.90
40500504	is highly vulnerable to	paper	0.90
Alzheimer's disease	associated_with	disease	0.90
Sirtuins	suppresses	protein	0.90
senescent glia	associated_with	unknown	0.90
mitochondrial_dysfunction	associated_with	mechanism	0.90
Obesity	associated_with	phenotype	0.88
LCA	suppresses	compound	0.85
KLHL22	associated_with	protein	0.85
lithocholic acid	prevents	drug	0.85
AMPK	inhibits	protein	0.85
Intrinsic Apoptosis	associated_with	pathway	0.85
mtDNA copy number	modulates	phenotype	0.80
mTOR	associated_with	pathway	0.80
MTOR	associated_with	protein	0.80
mtDNA Copy Number	associated_with	biomarker	0.75
mTOR pathway	regulates	pathway	0.70
low-grade inflammation	activates	process	0.70
mTOR	associated_with	protein	0.70
mTOR	regulates	protein	0.70
mitochondrial biogenesis	associated_with	process	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning AGEING in their description or question text

No additional research found