Contents

MOG Gene

🧬 Gene Info

Gene Symbol	MOG
Full Name	Myelin Oligodendrocyte Glycoprotein
Chromosome	6p22.2
Function	MOG is a type I transmembrane glycoprotein with an immunoglobulin-like domain.
Molecular Weight	28 kDa
Pathways	Complement, Oxidative Phosphorylation
NCBI Gene ID	4340
Ensembl ID	ENSG00000137355
GeneCards	MOG
Human Protein Atlas	MOG
Myelin surface localization	MOG is located on the outer surface of the myelin sheath, making it accessible to immune cells
Cell adhesion	MOG participates in oligodendrocyte process extension and myelin compaction
Complement activation	The extracellular domain can activate the complement cascade
Immunomodulation	Interacts with immune cells and may regulate T cell responses
Axon-oligodendrocyte signaling	May participate in bidirectional communication
Associated Diseases	AD, Aging, Als, Autoimmune, MOGAD
Known Drugs/Compounds	metformin
Interactions	AMPK, AND, APOPTOSIS, AQP4, ATG5, ATP
SciDEX Hypotheses	Oligodendrocyte White Matter Vulnerability
KG Connections	277 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

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