concept

HSV-1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSV-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

43Connections

0Hypotheses

0Analyses

30Outgoing

13Incoming

0Experiments

0Debates

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💡 Concept Info

Name	HSV-1
Key Genes/Proteins	A2M, APOE, APP, EIF2AK2, FAS, HSPG2
Related Diseases	Alzheimer's Disease, Alzheimer'S Disease, ALZHEIMER'S DISEASE

Wiki Pages (1)

Knowledge base pages for this entity

Valacyclovir for HSV-1-Positive Parkinson's Disease

clinical · 1036 words

→

Pathway Diagram

graph TD
    HSV_1["HSV-1"]
    HSV_1 -->|"binds"| HSPG2["HSPG2"]
    HSV_1 -->|"binds"| A2M["A2M"]
    HSV_1 -->|"promotes"| tau_phosphorylation["tau phosphorylation"]
    HSV_1 -->|"upregulates"| JAG1["JAG1"]
    HSV_1 -->|"interacts"| APOE["APOE"]
    HSV_1 -->|"involved_in"| Cholesterol_And_Lipid_Raft_Dep["Cholesterol And Lipid Raft-Dependent Uptake"]
    HSV_1 -->|"binds"| TFCP2["TFCP2"]
    OPTN["OPTN"] -->|"inhibits"| HSV_1
    MLKL["MLKL"] -->|"regulates"| HSV_1

Outgoing (30)

Target	Relation	Type	Str
Tau-related pathology	causes	phenotype	0.95
HSPG2	binds	protein	0.95
A2M	binds	protein	0.95
JAG1	upregulates	gene	0.92
Alzheimer'S Disease	risk_factor_for	disease	0.90
Nectin Receptors	enters_via	protein	0.90
A2M	binds_to	gene	0.90
cGAS-STING	activates	entity	0.90
A2M	binds	protein	0.90
Mitochondrial Dna	degrades	entity	0.85
Mitochondrial DNA Deletion	causes	process	0.85
Cholesterol And Lipid Raft-Dependent Uptake	involved_in	process	0.85
ALZHEIMER'S DISEASE	risk_factor_for	disease	0.85
Lipid Raft-Dependent Uptake	involved_in	process	0.85
TFCP2	binds	protein	0.85
APP	interacts_with	protein	0.80
TFCP2	binds	protein	0.80
EIF2AK2	inhibits	protein	0.80
PSEN1	interacts_with	protein	0.80
Mitochondrial Dna Damage	causes	mechanism	0.80
TAP2	inhibits	gene	0.80
Mitochondrial DNA	degrades	biomarker	0.80
APOPTOSIS	modulates	process	0.80
Alzheimer's Disease	risk_factor_for	disease	0.75
Alzheimer's Disease	associated_with	disease	0.75
FAS	regulates	gene	0.75
multiple sclerosis	associated_with	disease	0.70
Alzheimer's Disease	contributes_to	disease	0.70
MAPT	transports	protein	0.70
HSPG2	binds_to	protein	0.60

Incoming (13)

Source	Relation	Type	Str
18164103	binds to	paper	0.90
18164103	is transported to nucleus via	paper	0.90
18164103	activates	paper	0.90
APOE	modulates	protein	0.85
APP	interacts_with	protein	0.80
IL6	regulates	protein	0.80
IL1B	regulates	protein	0.80
MAPT	involved_in	gene	0.80
APOE	modifies_infectivity	gene	0.80
OPTN	inhibits	gene	0.80
APP	mediates	gene	0.75
MLKL	regulates	protein	0.70
MIRNAS	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity