concept

CGAS/STING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CGAS/STING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections

3Hypotheses

0Analyses

10Outgoing

4Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CGAS/STING

Pathway Diagram

graph TD
    CGAS_STING[CGAS/STING]
    CGAS_STING -->|activates| type_I_interferon[type I interferon]
    CGAS_STING -->|promotes| antitumor_T_cell_responses[antitumor T cell responses]
    CGAS_STING -->|involved_in| Innate_Immune_Response[Innate Immune Response]
    CGAS_STING -->|regulates| Cellular_Senescence[Cellular Senescence]
    CGAS_STING -->|contributes to| Oncogenesis[Oncogenesis]
    CGAS_STING -->|involved_in| ALS[ALS]
    CGAS_STING -->|modulates| Cancer_Development[Cancer Development]
    CGAS_STING -->|mediates| Cancer_Suppression[Cancer Suppression]
    CGAS_STING -->|contributes to| Amyotrophic_Lateral_Sclerosis[Amyotrophic Lateral Sclerosis]
    endogenous_DNA[endogenous DNA] -->|activates| CGAS_STING
    mitochondrial_DNA[mitochondrial DNA] -->|activates| CGAS_STING
    TARDBP[TARDBP] -->|activates| CGAS_STING
    LRRK2[LRRK2] -->|modulates| CGAS_STING

Outgoing (10)

Target	Relation	Type	Str
Cytosolic DNA	associated_with	compound	0.95
Innate Immune Response	involved_in	process	0.95
Cellular Senescence	regulates	process	0.95
type I interferon	activates	process	0.95
antitumor T cell responses	promotes	process	0.95
ALS	involved_in	disease	0.90
Oncogenesis	contributes_to	disease	0.90
Amyotrophic Lateral Sclerosis	contributes_to	disease	0.85
Cancer Development	modulates	process	0.85
Cancer Suppression	mediates	process	0.85

Incoming (4)

Source	Relation	Type	Str
mitochondrial DNA	activates	compound	0.90
TARDBP	activates	protein	0.90
endogenous DNA	activates	process	0.90
LRRK2	modulates	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Microglial IFN-β Priming of Motor Neuron cGAS/STING Amplific	0.720	neurodegeneration	What determines the specificity of TDP-4
Chronic cGAS/STING Hyperactivation Drives Progressive Neurod	0.660	neuroinflammation	How does chronic cGAS/STING activation d
Astrocyte cGAS/STING Activation Converts Protective into Des	0.580	neuroinflammation	How does chronic cGAS/STING activation d

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CGAS/STING in their description or question text

No additional research found