concept

MAPL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAPL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

54Connections

0Hypotheses

0Analyses

37Outgoing

17Incoming

0Experiments

0Debates

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💡 Concept Info

Name	MAPL
Key Genes/Proteins	AND, App, CANCER, CGAS, DNA, GASDERMIN
Related Diseases	Als, ALS, autism spectrum disorder, Cancer, Cell Survival

Pathway Diagram

graph TD
    MAPL["MAPL"]
    MAPL -->|"activates"| Pyroptosis["Pyroptosis"]
    MAPL -->|"promotes"| Mitochondrial_Dna["Mitochondrial Dna"]
    MAPL -->|"regulates"| Cell_Survival["Cell Survival"]
    MAPL -->|"promotes"| Inflammatory_Cell_Death["Inflammatory Cell Death"]
    MAPL -->|"regulates"| Cancer["Cancer"]
    MAPL -->|"activates"| Parkinson["Parkinson"]
    MAPL -->|"activates"| Als["Als"]
    MAPL -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    GASDERMIN["GASDERMIN"] -->|"regulates"| MAPL
    VPS35["VPS35"] -->|"activates"| MAPL
    PYROPTOSIS["PYROPTOSIS"] -->|"activates"| MAPL
    CGAS["CGAS"] -->|"regulates"| MAPL
    MITOCHONDRIA["MITOCHONDRIA"] -->|"activates"| MAPL
    MTDNA["MTDNA"] -->|"regulates"| MAPL
    DNA["DNA"] -->|"regulates"| MAPL
    LRRK2["LRRK2"] -->|"activates"| MAPL

Outgoing (37)

Target	Relation	Type	Str
Pyroptosis	activates	process	0.95
Pyroptosis	associated_with	process	0.95
Mitochondrial DNA Trafficking	associated_with	process	0.90
Mitochondrial Dna	promotes	compound	0.90
Mitochondrial DNA	transports	compound	0.90
Cell Survival	regulates	phenotype	0.85
Inflammatory Cell Death	promotes	process	0.85
pyroptotic cell death	promotes	process	0.80
ALS	activates	disease	0.65
Parkinson	activates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Cancer	regulates	disease	0.65
Als	activates	disease	0.65
Macrophage	inhibits	cell_type	0.60
PARKINSON	activates	gene	0.60
LRRK2	activates	gene	0.60
pyroptosis	activates	process	0.60
MTDNA	regulates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
DNA	regulates	gene	0.60
VPS35	inhibits	gene	0.60
GASDERMIN	regulates	gene	0.60
LRRK2	inhibits	gene	0.60
CGAS	regulates	gene	0.60
PYROPTOSIS	activates	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
pyroptosis	participates_in	pathway	0.60
autism spectrum disorder	activates	disease	0.60
Parkinson's disease	activates	disease	0.60
macrophages	expressed_in	cell_type	0.60
VPS35	activates	gene	0.60
Raf	activates	protein	0.60
Ubiquitin	regulates	protein	0.60
App	activates	protein	0.60
UBIQUITIN	regulates	gene	0.60
AND	activates	gene	0.60
Macrophage	expressed_in	cell_type	0.55

Incoming (17)

Source	Relation	Type	Str
Parkinson's Disease	associated_with	disease	0.75
GASDERMIN	regulates	gene	0.60
VPS35	activates	gene	0.60
PYROPTOSIS	activates	gene	0.60
CGAS	regulates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
MTDNA	regulates	gene	0.60
DNA	regulates	gene	0.60
LRRK2	activates	gene	0.60
LYSOSOME	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
GENES	activates	gene	0.60
CANCER	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
MITOCHONDRIAL DNA	activates	gene	0.60
DNA	activates	gene	0.60
LRRK2	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MAPL in their description or question text

No additional research found