| Gene Symbol | MANF |
| Aliases | Mesencephalic Astrocyte-Derived Neurotrophic Factor |
| Function | encodes a unique neurotrophic factor with distinctive mechanisms of action distinct from classical neurotrophic factors like BDNF or GDNF. |
| Subcellular Localization | </th><td>Secreted, Endoplasmic Reticulum, Cytoplasm</td></tr> |
| Molecular Weight | 20 kDa |
| Amino Acids | 182 aa |
| Exons | 4 |
| Pathways | Amyloid, Immune Response, Lipid Metabolism, Mitophagy, Oxidative Stress |
| Ensembl ID | ENSG00000131791 |
| GeneCards | MANF |
| Human Protein Atlas | MANF |
| N-terminal domain (1-60 aa) | Contains an ER retention signal sequence (RTDL) that directs protein to the endoplasmic reticulum. This region is rich in arginine residues and contributes to protein-protein interactions. |
| C-terminal domain (61-182 aa) | The secreted portion of MANF contains the neurotrophic activity. This domain adopts a stable three-dimensional fold with disulfide bonds that maintain structural integrity. |
| Cys-rich regions | Four conserved cysteine residues form two disulfide bonds (Cys71-Cys98 and Cys103-Cys133), creating a cysteine-pair motif characteristic of the MANF family. |
| Signal peptide (1-23 aa) | Enables secretion via the classical secretory pathway when the ER retrieval signal is not engaged. |
| Associated Diseases | breast cancer cell survival, PRKN E3 ligase activity |
| Interactions | ACHE, ALZHEIMER, APOPTOSIS, ATF4, AXON, BPMC |
| KG Connections | 149 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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