| Gene Symbol | MANF |
| Aliases | Mesencephalic Astrocyte-Derived Neurotrophic Factor |
| Function | encodes a unique neurotrophic factor with distinctive mechanisms of action distinct from classical neurotrophic factors like BDNF or GDNF. |
| Molecular Weight | 20 kDa |
| Amino Acids | 182 aa |
| Exons | 4 |
| Pathways | Amyloid, Immune Response, Lipid Metabolism, Mitophagy, Oxidative Stress |
| Ensembl ID | ENSG00000131791 |
| GeneCards | MANF |
| Human Protein Atlas | MANF |
| Exon 1 | Encodes the signal peptide and N-terminal portion |
| Exon 2-4 | Encode the C-terminal secreted domain with cysteine-rich regions |
| Associated Diseases | breast cancer cell survival, PRKN E3 ligase activity |
| Interactions | ACHE, ALZHEIMER, APOPTOSIS, ATF4, AXON, BPMC |
| KG Connections | 149 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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