| Gene Symbol | MLCK |
| Full Name | Myosin light chain kinase |
| Chromosome | 3p21.31 |
| Protein Type | Kinase |
| Target Class | Kinase |
| Function | MLCK inhibitors block the phosphorylation of myosin light chains, thereby reducing cytoskeletal contraction and stabilizing tight junctions at the blood-brain barrier and endothelial surfaces. This... |
| Mechanism of Action | MLCK inhibitors block the phosphorylation of myosin light chains, thereby reducing cytoskeletal contraction and stabilizing tight junctions at the blood-brain barrier and endothelial surfaces. This mechanism reduces vascular permeability and preserves barrier integrity in conditions characterized by excessive leakage or cytoskeletal dysfunction. |
| Primary Expression | Brain (cerebellum), Smooth muscle, Heart |
| Druggability | Low (0.40) |
| Clinical Stage | Phase II |
| Molecular Weight | 220 kDa |
| Gene Type | Protein coding |
| Pathways | Nf-Κb |
| UniProt ID | Q9Y463 |
| NCBI Gene ID | 3371 |
| Ensembl ID | ENSG00000139792 |
| OMIM | 600922 |
| GeneCards | MLCK |
| Human Protein Atlas | MLCK |
| Associated Diseases | ALS, neurodegeneration, stroke |
| Known Drugs/Compounds | Lifibrate |
| Interactions | Actin, AHR, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AND |
| SciDEX Target | View Target Profile (4 clinical trials) |
| KG Connections | 284 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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