Contents

KEAP1 - Kelch-like ECH-Associated Protein 1

🔬 Protein Info

Gene Symbol	KEAP1
Full Name	Kelch-like ECH-Associated Protein 1
Aliases	Page for KEAP1
Protein Type	Adaptor Protein
Function	High-Affinity Binding: ETGE motif of NRF2 binds to one Kelch domain (hinge)
Molecular Weight	70 kDa
Amino Acids	624 aa
Pathways	Akt, Apoptosis, Autophagy, Cell Cycle, Differentiation
UniProt ID	Q14145
GeneCards	KEAP1
Human Protein Atlas	KEAP1
Associated Diseases	Aging, Als, Alzheimer, AUTOPHAGY, Cancer
Known Drugs/Compounds	DOXORUBICIN, Epalrestat, EPALRESTAT, EPS, Fumarate, gastrodin
Interactions	ACHE, ACOD1, Actin, AD, AGING, AIFM1
KG Connections	1193 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

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Knowledge Graph

NRF2 interacts_with KEAP1

NRF2 inhibits KEAP1

KEAP1 regulates NRF2

KEAP1 interacts_with CUL3

KEAP1 associated_with CCRCC

EPS interacts_with KEAP1

P62 interacts_with KEAP1

KEAP1 activates NRF2

KEAP1 activates ULK1